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- W85451694 abstract "A pentaspan membrane glycoprotein prominin-1 (frequently called CD133 in human) is widely used as a surface marker to identify and isolate normal stem/progenitor cells from various organs, although it is also expressed in some types of differentiated cells. Since CD133 was identified as a universal marker to isolate cancer stem cells (CSCs) in tumors derived from multiple tissues, much attention has been directed toward the relationship between its gene regulation and identity of CSCs (i.e., cancer stemness). Prominin-1 (PROM1) gene possesses five alternative promoters yielding multiple first exons within the 5'-untranslated region (UTR) and also splicing variants affecting the open reading frame (ORF) sequence, implicating the complicated gene regulation in a context-dependent manner. This chapter aims to organize the accumulated findings on prominin-1 with a focus on its altered expression and regulation in normal and cancerous cells and to discuss potential regulatory networks underlying cancer stemness." @default.
- W85451694 created "2016-06-24" @default.
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- W85451694 date "2012-11-05" @default.
- W85451694 modified "2023-10-05" @default.
- W85451694 title "Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues" @default.
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- W85451694 doi "https://doi.org/10.1007/978-1-4614-5894-4_5" @default.
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