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- W85453111 abstract "The engrailed genes belong to a large family of homeobox transcription factors. They are found throughout the animal kingdom, are highly conserved in the DNA binding domain and have been investigated for more than half a century. In the murine genome, two engrailed genes exist, called Engrailed-1 and Engrailed-2. Here, we summarize the properties of the engrailed genes and their functions, such as conserved structures, cellular localisation, secretion and internalisation, transcription factor activity, potential target genes and review their role in the development of mesencephalic dopaminergic neurons. During early development, they take part in the regionalization event, which specifies the neuroepithelium that provides the precursor cells of the mesencephalic dopaminergic neurons with the necessary signals for their induction. Later in the post-mitotic neurons, the two transcription factors participate in their specification and are cell-autonomously required for their survival." @default.
- W85453111 created "2016-06-24" @default.
- W85453111 creator A5038180846 @default.
- W85453111 creator A5052084035 @default.
- W85453111 date "2006-01-01" @default.
- W85453111 modified "2023-09-26" @default.
- W85453111 title "The engrailed transcription factors and the mesencephalic dopaminergic neurons" @default.
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- W85453111 doi "https://doi.org/10.1007/978-3-211-45295-0_9" @default.
- W85453111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17017508" @default.
- W85453111 hasPublicationYear "2006" @default.
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