Matches in SemOpenAlex for { <https://semopenalex.org/work/W85455198> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W85455198 endingPage "356" @default.
- W85455198 startingPage "351" @default.
- W85455198 abstract "The effects of 5-hydroxytryptamine (5-HT) on nerve fibres in the rabbit cervical vagus and on the sciatic nerve in vitro were studied by the single sucrose-gap technique. The addition of 5-HT to the Locke solution bathing the vagus nerve induced rapid depolarization and a fall in spike height at the threshold concentration of 1 X 10(-7) M. In most cases the depolarizing effect was completely reversed by washing 5--10 min while in about 40% of the preparations the action potential amplitude remained 10--30% below the control level. These effects were dose-related up to a maximum concentration of 3 X 10(-5) M. Tachyphylaxis was not observed when the drug was added at 12--15 min intervals. Depolarization was abolished by perfusing the nerve with sodium-free medium or by previous exposure to lidocaine (10(-3) M). External hyperpolarizing currents (10(-7) to 10(-6) A) were not able to restore the action potential amplitude. Cyproheptadine (50 micron), which was found to have a slight local anesthetic action, reduced the 5-HT-induced depolarization by 20--30%. Methysergide (50 micron), a more specific 5-HT antagonist, did not affect the action of 5-HT. 5-HT was inactive when applied to the myelinated fibres of the sciatic nerve. Our results indicate that 5-HT-induced depolarization appears to be related to an increase in the resting sodium permeability of nerve fibres." @default.
- W85455198 created "2016-06-24" @default.
- W85455198 creator A5018762929 @default.
- W85455198 date "1978-06-01" @default.
- W85455198 modified "2023-09-27" @default.
- W85455198 title "The depolarizing action of 5-HT on mammalian non-myelinated nerve fibres" @default.
- W85455198 cites W1964555836 @default.
- W85455198 cites W1966169824 @default.
- W85455198 cites W1968787922 @default.
- W85455198 cites W1969732264 @default.
- W85455198 cites W1995035698 @default.
- W85455198 cites W2008500733 @default.
- W85455198 cites W2010172924 @default.
- W85455198 cites W2065138346 @default.
- W85455198 cites W2068507518 @default.
- W85455198 cites W2123369785 @default.
- W85455198 cites W4247879046 @default.
- W85455198 doi "https://doi.org/10.1016/0014-2999(78)90308-4" @default.
- W85455198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/668806" @default.
- W85455198 hasPublicationYear "1978" @default.
- W85455198 type Work @default.
- W85455198 sameAs 85455198 @default.
- W85455198 citedByCount "66" @default.
- W85455198 crossrefType "journal-article" @default.
- W85455198 hasAuthorship W85455198A5018762929 @default.
- W85455198 hasConcept C12554922 @default.
- W85455198 hasConcept C126322002 @default.
- W85455198 hasConcept C170493617 @default.
- W85455198 hasConcept C185592680 @default.
- W85455198 hasConcept C24998067 @default.
- W85455198 hasConcept C2775864247 @default.
- W85455198 hasConcept C2781005078 @default.
- W85455198 hasConcept C2781149210 @default.
- W85455198 hasConcept C2781404750 @default.
- W85455198 hasConcept C29852270 @default.
- W85455198 hasConcept C4141045 @default.
- W85455198 hasConcept C42219234 @default.
- W85455198 hasConcept C55493867 @default.
- W85455198 hasConcept C71924100 @default.
- W85455198 hasConcept C86803240 @default.
- W85455198 hasConceptScore W85455198C12554922 @default.
- W85455198 hasConceptScore W85455198C126322002 @default.
- W85455198 hasConceptScore W85455198C170493617 @default.
- W85455198 hasConceptScore W85455198C185592680 @default.
- W85455198 hasConceptScore W85455198C24998067 @default.
- W85455198 hasConceptScore W85455198C2775864247 @default.
- W85455198 hasConceptScore W85455198C2781005078 @default.
- W85455198 hasConceptScore W85455198C2781149210 @default.
- W85455198 hasConceptScore W85455198C2781404750 @default.
- W85455198 hasConceptScore W85455198C29852270 @default.
- W85455198 hasConceptScore W85455198C4141045 @default.
- W85455198 hasConceptScore W85455198C42219234 @default.
- W85455198 hasConceptScore W85455198C55493867 @default.
- W85455198 hasConceptScore W85455198C71924100 @default.
- W85455198 hasConceptScore W85455198C86803240 @default.
- W85455198 hasIssue "4" @default.
- W85455198 hasLocation W854551981 @default.
- W85455198 hasLocation W854551982 @default.
- W85455198 hasOpenAccess W85455198 @default.
- W85455198 hasPrimaryLocation W854551981 @default.
- W85455198 hasRelatedWork W1866600283 @default.
- W85455198 hasRelatedWork W2021245898 @default.
- W85455198 hasRelatedWork W2044659416 @default.
- W85455198 hasRelatedWork W2045167702 @default.
- W85455198 hasRelatedWork W2053390921 @default.
- W85455198 hasRelatedWork W2300322402 @default.
- W85455198 hasRelatedWork W2392469664 @default.
- W85455198 hasRelatedWork W2414016209 @default.
- W85455198 hasRelatedWork W2999723970 @default.
- W85455198 hasRelatedWork W85455198 @default.
- W85455198 hasVolume "49" @default.
- W85455198 isParatext "false" @default.
- W85455198 isRetracted "false" @default.
- W85455198 magId "85455198" @default.
- W85455198 workType "article" @default.