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- W854611062 startingPage "2601" @default.
- W854611062 abstract "目的：探讨表皮生长因子4（ERBB4）基因多态性与精神分裂症及发病年龄的遗传关联。方法：应用病例对照遗传关联研究设计,采用TaqMan技术检测方法,检测并分析768例精神分裂症患者和813例年龄、性别、民族匹配的正常对照者中ERBB4基因的5个单核苷酸多态性（SNP）位点与精神分裂症及发病年龄的关联。结果：ERBB4基因的4个SNPs多态性位点与精神分裂症显著关联（rs1851185,C〉T,x2=4.37,P=0.036;rs6435689,C〉T,x2=6.772,P=0.009;rs11887531,C〉T,x2=6.876,P=0.008;rs12468336,C〉T,χ2=6.443,P=0.011）与精神分裂症关联,由rs11887531-rs12468336-rs16847823组成的单体型CCC与精神分裂症关联（x2=7.519,P=0.006）,并与精神分裂症发病年龄关联（CCC携带者20.17±3.87岁,非CCC携带者23.01±4.85岁,t=2.98,P=0.032）。结论：ERBB4基因多态性可能与精神分裂症发病机制关联。" @default.
- W854611062 created "2016-06-24" @default.
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- W854611062 date "2010-01-01" @default.
- W854611062 modified "2023-09-24" @default.
- W854611062 title "精神分裂症与表皮生长因子4（ERBB4）基因多态性的关联研究" @default.
- W854611062 hasPublicationYear "2010" @default.
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