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- W85464595 abstract "Abstract A series of monoclonal antibodies that define B cell restricted and associated antigens was utilized in an attempt to characterize tumors of B lineage and to relate these tumors to B cell differentiative stages. Antigens that were previously shown to be B cell restricted on normal B lymphocytes were similarly expressed only on B cell malignancies. In contrast, antigens that were B cell associated were also found on tumors of other lineages. Moreover, on the basis of cell surface phenotypes, tumors of B cell origin were divided into three major subgroups, which corresponded to the level of differentiation of the malignant tumor cell: pre-B cell stage (non-T acute lymphoblastic leukemia and chronic myelocytic leukemia in lymphoid blast crisis); the mid-B cell stage (chronic lymphocytic leukemia, poorly differentiated lymphomas); and secretory B cell stage (large cell lymphomas and plasma cell tumors). A hypothetical model is derived that relates the malignant B cell to its normal cellular counterpart on the basis of cell surface expression of this panel of B cell-restricted and B cell- associated antigens." @default.
- W85464595 created "2016-06-24" @default.
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- W85464595 date "1984-06-01" @default.
- W85464595 modified "2023-10-14" @default.
- W85464595 title "Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation" @default.
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- W85464595 doi "https://doi.org/10.1182/blood.v63.6.1424.1424" @default.
- W85464595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6609729" @default.
- W85464595 hasPublicationYear "1984" @default.
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