Matches in SemOpenAlex for { <https://semopenalex.org/work/W854653867> ?p ?o ?g. }
- W854653867 abstract "The heartbeat originates within the sinoatrial node (SA node or SAN), a small highly specialized structure containing <10,000 genuine pacemaker cells. The ~5 billion working cardiomyocytes downstream of the SAN remain quiescent when it fails, leading to circulatory collapse and fueling a $6B/year electronic pacemaker industry. The electronic pacemaker devices work quite well. But, device-related problems persist. These include lead failure/repositioning, finite battery life, and infection. For pediatric patients, the children outgrow the length of the leads, necessitating replacement with longer leads. These pitfalls have motivated creation of biological pacing. that are free from all hardware. Toward this goal, we and others have tested the concept of biological pacemakers. Combined with efforts to create clinically relevant, large animal models of biological pacing, the field is moving beyond a conceptual novelty toward a future with clinical reality." @default.
- W854653867 created "2016-06-24" @default.
- W854653867 creator A5052909220 @default.
- W854653867 date "2015-06-27" @default.
- W854653867 modified "2023-10-17" @default.
- W854653867 title "Pacing the Heart with Genes: Recent Progress in Biological Pacing" @default.
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- W854653867 doi "https://doi.org/10.1007/s11886-015-0620-x" @default.
- W854653867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8552987" @default.
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