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- W85504119 abstract "In the past two decades, there has been increasing concern about the potentially adverse effects of exogenous endocrine active substances (EAS) that alter the function of the endocrine system by interfering with hormone regulation. The mechanistic pathways by which EAS may elicit adverse effects, such as developmental and reproductive toxicity, often involve direct binding to nuclear hormone receptors. Certainly, the best studied nuclear receptor is the estrogen receptor (ER). Large-scale in vitro and in vivo methods have been developed to assess the estrogenic toxicity of chemicals. However, there are financial and animal welfare concerns related to their application. Quantitative structure-activity relationship (QSAR) approaches have proven their utility as a priority setting tool in the risk assessment of EAS. In addition, the models help to clarify the binding mode of the interacting substances. As estrogen-mediated effects are usually related to ligand-receptor interactions, and as there have been comprehensive structural studies on the ER, molecular modeling together with other in silico approaches provide a suitable means of studying these estrogenic effects. This chapter provides an overview of the molecular modeling approaches applied to ligand-ER interactions. The progress in the field is outlined, and some critical issues are analyzed based on recently published models where these approaches are applied." @default.
- W85504119 created "2016-06-24" @default.
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- W85504119 date "2011-01-01" @default.
- W85504119 modified "2023-09-25" @default.
- W85504119 title "Recent Advances in the Molecular Modeling of Estrogen Receptor-Mediated Toxicity" @default.
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- W85504119 cites W1967983823 @default.
- W85504119 cites W1968826930 @default.
- W85504119 cites W1970451752 @default.
- W85504119 cites W1971459249 @default.
- W85504119 cites W1973836078 @default.
- W85504119 cites W1976396917 @default.
- W85504119 cites W1984018221 @default.
- W85504119 cites W1984811139 @default.
- W85504119 cites W1985588649 @default.
- W85504119 cites W1990164858 @default.
- W85504119 cites W1990529844 @default.
- W85504119 cites W1999466810 @default.
- W85504119 cites W1999896243 @default.
- W85504119 cites W2002063031 @default.
- W85504119 cites W2002067669 @default.
- W85504119 cites W2003534920 @default.
- W85504119 cites W2005690825 @default.
- W85504119 cites W2006961531 @default.
- W85504119 cites W2007331274 @default.
- W85504119 cites W2008420174 @default.
- W85504119 cites W2008494508 @default.
- W85504119 cites W2009949097 @default.
- W85504119 cites W2027392147 @default.
- W85504119 cites W2032992521 @default.
- W85504119 cites W2034726356 @default.
- W85504119 cites W2035035284 @default.
- W85504119 cites W2035120653 @default.
- W85504119 cites W2036121643 @default.
- W85504119 cites W2039544775 @default.
- W85504119 cites W2040053707 @default.
- W85504119 cites W2049229941 @default.
- W85504119 cites W2050456292 @default.
- W85504119 cites W2051655433 @default.
- W85504119 cites W2055878543 @default.
- W85504119 cites W2056593372 @default.
- W85504119 cites W2062382930 @default.
- W85504119 cites W2064215336 @default.
- W85504119 cites W2064922889 @default.
- W85504119 cites W2065695329 @default.
- W85504119 cites W2067455153 @default.
- W85504119 cites W2068672372 @default.
- W85504119 cites W2069107763 @default.
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- W85504119 cites W2073746660 @default.
- W85504119 cites W2077601978 @default.
- W85504119 cites W2080570874 @default.
- W85504119 cites W2080653934 @default.
- W85504119 cites W2085124463 @default.
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- W85504119 cites W2169600586 @default.
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- W85504119 doi "https://doi.org/10.1016/b978-0-12-386485-7.00006-5" @default.
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