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• W855084716 abstract "Radioimmunotherapy (RIT) is a therapeutic modality that allows delivering of ionizing radiation (IR) directly to targeted cancer cells. Conventional RIT uses β-emitting radioisotopes, but recently a growing interest has emerged for the clinical development of α particles. Alpha emitters are ideal for killing isolated or small clusters of tumor cells thanks to their high linear energy transfer and short path in tissue. Their efficacy is also less sensitive to dose rate, tissue oxygenation or cell cycle status. In parallel, growing evidence has shown that IR can foster an anti-tumor immune response through the induction of immunogenic cell death. Several studies have described α emitter radiobiology but little is known about cell death mechanisms induced after α radiation and no investigation has been undertaken to analyze the impact of α particles on the immune response. Therefore, we decided to investigate the molecular mechanisms of cell response and immunogenicity of tumor cells after bismuth-213 (213Bi) irradiation. In vitro studies demonstrated that 213Bi treated cells undergo cell cycle arrest in G2 phase, activate autophagy, release DAMPs and activate dendritic cells. Besides, vaccination of immunocompetent mice with 213Bi irradiated tumor cells induce a protective anti-tumor response in vivo that is mediated by tumor specific T cells. Our results demonstrate that α irradiation can stimulate adaptive immunity and elicit an efficient anti-tumour protection. Even though the impact of α radiation on the immune response to cancer will have to be further characterized, this study opens new perspectives for combinatory treatments using α RIT with immunotherapy." @default.
• W855084716 created "2016-06-24" @default.
• W855084716 creator A5024785562 @default.
• W855084716 date "2013-01-01" @default.
• W855084716 modified "2023-09-27" @default.
• W855084716 title "Contribution à l'étude de la radiobiologie des émetteurs de particules alpha et de leur impact sur l'immunogénicité des tumeurs" @default.
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