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- W855293562 abstract "Signal transduction cascades are utilized by all organisms to convey signals perceived at the cell surface to effectors within the cell. These enzymatic signaling cascades are important in the pathogenesis of many infections, including cryptococcosis. This chapter summarizes the significance and functional interactions involved in the cell wall integrity, phospholipase, and calcineurin signaling pathways for the establishment of Cryptococcus neoformans virulence. The fungal Plc enzymes referred to in this review preferentially hydrolyze phosphatidylinositol (PI)-based substrates within the cryptococcal cell and affect multiple cellular functions, including the secretion of (phospholipase B ) Plb1. It was found that the Plb1 MW could be as high as 125 kDa due to extensive asparagine N-linked glycosylation, which is responsible for at least 30% of the MW of Plb1 and essential for its activity. It was recently demonstrated that PI-PLC1 (Plc1) regulates cryptococcal virulence, acting in part through interactions with the Pkc/Mpk1 cell wall integrity pathway. In contrast to Plcs from higher eukaryotes, Plcs from the parasite Trypanosoma brucei preferentially hydrolyze the glycosylphosphatidylinositol (GPI) anchor of variant surface glycoprotein or GPI biosynthetic intermediates, in addition to PI, but not the phosphorylated intermediates, despite their localization to the peripheral cytoplasmic face of intracellular vesicles. Metabolic labeling studies performed in S. cerevisiae implicated a Plc enzyme and a secondary-acting protease in hydrolysis of the GPI anchor of certain proteins in the plasma membrane, resulting in their subsequent localization in the cell wall. ScPlc1, the only Plc1 in S. cerevisiae, like CnPlc1, lacks a secretory signal leader peptide." @default.
- W855293562 created "2016-06-24" @default.
- W855293562 creator A5022370216 @default.
- W855293562 creator A5045916438 @default.
- W855293562 creator A5072330637 @default.
- W855293562 date "2014-04-09" @default.
- W855293562 modified "2023-09-25" @default.
- W855293562 title "Signaling Cascades and Enzymes as Cryptococcus Virulence Factors" @default.
- W855293562 cites W1536320539 @default.
- W855293562 cites W1560448629 @default.
- W855293562 cites W1564367795 @default.
- W855293562 cites W1573671038 @default.
- W855293562 cites W1586693095 @default.
- W855293562 cites W1842106696 @default.
- W855293562 cites W1895206111 @default.
- W855293562 cites W1895329547 @default.
- W855293562 cites W1923816168 @default.
- W855293562 cites W1947611647 @default.
- W855293562 cites W1958742527 @default.
- W855293562 cites W1964900779 @default.
- W855293562 cites W1965493726 @default.
- W855293562 cites W1966322334 @default.
- W855293562 cites W1966495804 @default.
- W855293562 cites W1968834637 @default.
- W855293562 cites W1972297273 @default.
- W855293562 cites W1974991804 @default.
- W855293562 cites W1977852240 @default.
- W855293562 cites W1979228758 @default.
- W855293562 cites W1980166477 @default.
- W855293562 cites W1981480550 @default.
- W855293562 cites W1982958726 @default.
- W855293562 cites W1984754431 @default.
- W855293562 cites W1987415607 @default.
- W855293562 cites W1989491358 @default.
- W855293562 cites W1990249568 @default.
- W855293562 cites W1991674117 @default.
- W855293562 cites W1996218114 @default.
- W855293562 cites W1996603036 @default.
- W855293562 cites W1996677209 @default.
- W855293562 cites W1997030121 @default.
- W855293562 cites W2001541852 @default.
- W855293562 cites W2005527978 @default.
- W855293562 cites W2007580140 @default.
- W855293562 cites W2008062150 @default.
- W855293562 cites W2010664915 @default.
- W855293562 cites W2014041528 @default.
- W855293562 cites W2014547753 @default.
- W855293562 cites W2022227140 @default.
- W855293562 cites W2025389666 @default.
- W855293562 cites W2027220020 @default.
- W855293562 cites W2027546225 @default.
- W855293562 cites W2028658891 @default.
- W855293562 cites W2028938587 @default.
- W855293562 cites W2034745870 @default.
- W855293562 cites W2037036397 @default.
- W855293562 cites W2038736974 @default.
- W855293562 cites W2038778410 @default.
- W855293562 cites W2040518083 @default.
- W855293562 cites W2040773127 @default.
- W855293562 cites W2042092509 @default.
- W855293562 cites W2044053799 @default.
- W855293562 cites W2045508653 @default.
- W855293562 cites W2045786452 @default.
- W855293562 cites W2046124843 @default.
- W855293562 cites W2046827613 @default.
- W855293562 cites W2047090400 @default.
- W855293562 cites W2049074441 @default.
- W855293562 cites W2051084649 @default.
- W855293562 cites W2054868502 @default.
- W855293562 cites W2055103502 @default.
- W855293562 cites W2056379655 @default.
- W855293562 cites W2058902988 @default.
- W855293562 cites W2059140883 @default.
- W855293562 cites W2059599738 @default.
- W855293562 cites W2061121927 @default.
- W855293562 cites W2064059521 @default.
- W855293562 cites W2066790438 @default.
- W855293562 cites W2074707482 @default.
- W855293562 cites W2081581252 @default.
- W855293562 cites W2085784534 @default.
- W855293562 cites W2086181643 @default.
- W855293562 cites W2086524338 @default.
- W855293562 cites W2088296811 @default.
- W855293562 cites W2088806330 @default.
- W855293562 cites W2093005137 @default.
- W855293562 cites W2093226304 @default.
- W855293562 cites W2093736932 @default.
- W855293562 cites W2094866428 @default.
- W855293562 cites W2095699986 @default.
- W855293562 cites W2096833920 @default.
- W855293562 cites W2096985979 @default.
- W855293562 cites W2100275023 @default.
- W855293562 cites W2100317350 @default.
- W855293562 cites W2104663609 @default.
- W855293562 cites W2105634866 @default.
- W855293562 cites W2108316682 @default.
- W855293562 cites W2108666301 @default.
- W855293562 cites W2109483555 @default.