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- W855451976 abstract "Publisher Summary In this chapter, the effect of damage to the nucleus tractus solitarii (NTS) on blood pressure, heart rate, and baroreceptor reflex responses is studied under acute and chronic conditions. When located at the level of the area postrema or just rostral from it, bilateral electrolytic lesions of the NTS of normotensive Wistar rats acutely cause hypertension. A slight tachycardia is observed in the first group. Extensive lesions also cause hypertension, but no change of heart rate is found. Lesions located more caudally in the NTS and in the nucleus commissuralis are ineffective. A similar type of acute hypertension occurs after bilateral transections just lateral to the NTS at the level of the area postrema. Effective transections are found to extend into the reticular formation between the NTS and the nucleus tractus spinalis n. trigemini. Bilateral transection of the tractus failed to cause hypertension. Removal of the area postrema does not affect either blood pressure or heart rate. Electrical stimulation of the NTS causes frequency dependent hypotension and bradycardia. These data may indicate that the cells of the NTS mediate a tonic inhibitory influence on blood pressure. The effect of the lesions located at the level of the area postrema is also studied in the chapter under chronic conditions." @default.
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- W855451976 date "1977-01-01" @default.
- W855451976 modified "2023-10-03" @default.
- W855451976 title "Acute and Chronic Hypertension after Lesions and Transections of the Rat Brain Stem" @default.
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- W855451976 doi "https://doi.org/10.1016/s0079-6123(08)62725-9" @default.
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