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- W855792372 abstract "The bacterial allosteric regulator and secondary messenger cyclic di-GMP (c-di-GMP) plays an integral role in the life cycle of pathogenic Vibrio cholerae by helping to mediate the environment-to-host transition. The regulation of the intracellular concentration of c-di-GMP in V. cholerae is complex, as there is an abundance of genes coding for diguanylate cyclases (DGCs) and phosphodiesterase (PDEs). This chapter focuses on the role of c-di-GMP in the regulation of V. cholerae virulence mechanisms during colonization and dissemination. The two most important virulence factors expressed by V. cholerae are cholera toxin (CT) and the toxin-coregulated pilus (TCP). In vitro expression studies have shown that c-di-GMP has a negative effect on virulence gene expression, specifically CT. Although V. cholerae motility has been well studied, the role of motility in pathogenesis remains unclear. There is an abundance of information regarding physiological behaviors regulated by c-di-GMP, but relatively little is known about the mechanism(s) of this regulation. It is understood that the intracellular concentration of c-di-GMP is modulated by the enzymatic activities of DGCs and PDEs, but it is not known how these changes in concentration signal for the vast alterations in bacterial behavior are observed. Identification of new regulatory pathways will provide new insight into the cdi-GMP regulatory circuit and will help to explain how this secondary messenger molecule is so important to V. cholerae pathogenesis and environmental fitness." @default.
- W855792372 created "2016-06-24" @default.
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- W855792372 creator A5009524336 @default.
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- W855792372 date "2014-04-30" @default.
- W855792372 modified "2023-09-26" @default.
- W855792372 title "Role of Cyclic Di-GMP in Vibrio cholerae Virulence" @default.
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- W855792372 doi "https://doi.org/10.1128/9781555816667.ch20" @default.
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