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- W85580261 abstract "This chapter presents a study examining the enhanced natural killer (NK) activity in patients treated by interferon-α relation to clinical response. NK activity was measured by a 4-h 51Cr release assay using Chang cells as targets. In 83 patients, NK activity was measured prior to and during interferon (IFN)-therapy, which, in most cases, consisted of 3 × 106 IFN units daily. In 74 of these patients (90%), NK activity increased following the first injection of IFN, as measured 24 h after the injection. The increase was statistically significant (p < 0.001). Some patients received 1, 5, or 6 × 106 IFN units daily instead of 3 × 106 units. There was an inverse relationship between the IFN dose and the relative enhancement of NK activity. NK activity was also measured after 1 week, 3 months, 6 months, 9 months, and 12 months of IFN therapy. NK activity was increased in a majority of the patients at all these time points. The increase was in all cases but one was statistically significant." @default.
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- W85580261 date "1982-01-01" @default.
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- W85580261 title "ENHANCED NK ACTIVITY IN PATIENTS TREATED BY INTERFERON-α. RELATION TO CLINICAL RESPONSE" @default.
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- W85580261 doi "https://doi.org/10.1016/b978-0-12-341360-4.50186-4" @default.
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