FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W85585032> ?p ?o ?g. }

• W85585032 endingPage "12" @default.
• W85585032 startingPage "7" @default.
• W85585032 abstract "Hematoma and perihematomal regions after intracerebral hemorrhage (ICH) are biochemically active environments known to undergo potent oxidizing reactions. We report facile production of bilirubin oxidation products (BOXes) via hemoglobin=Fenton reaction under conditions approximating putative in vivo conditions seen following ICH. Using a mixture of human hemoglobin, physiological buffers, uncon-jugated solubilized bilirubin, and molecular oxygen and=or hydrogen peroxide, we generated BOXes, confirmed by spectral signature consistent with known BOXes mixtures produced by independent chemical synthesis, as well as HPLC-MS of BOX A and BOX B. Kinetics are straightforward and uncomplicated, having initial rates around 0.002 µM bilirubin per mM hemoglobin per second under normal experimental conditions. In hematomas from porcine ICH model, we observed significant production of BOXes, malondialdehyde, and superoxide dismutase, indicating a potent oxidizing environment. BOX concentrations increased from 0.084 ± 0.01 in fresh blood to 22.24 ± 4.28 in hematoma at 72h, and were 11.22 ±1.90 in adjacent white matter (nmol/g). Similar chemical and analytical results are seen in ICH in vivo, indicating the hematoma is undergoing similar potent oxidations. This is the first report of BOXes production using a well-defined biological reaction and in vivo model of same. Following ICH, amounts of unconjugated bilirubin in hematoma can be substantial, as can levels of iron and hemoglobin. Oxidation of unconjugated bilirubin to yield bioactive molecules, such as BOXes, is an important discovery, expanding the role of bilirubin in pathological processes seen after ICH." @default.
• W85585032 created "2016-06-24" @default.
• W85585032 creator A5006724619 @default.
• W85585032 creator A5009866471 @default.
• W85585032 creator A5021539455 @default.
• W85585032 creator A5031142537 @default.
• W85585032 creator A5055042810 @default.
• W85585032 creator A5057605812 @default.
• W85585032 creator A5082999475 @default.
• W85585032 date "2009-02-26" @default.
• W85585032 modified "2023-10-13" @default.
• W85585032 title "Bilirubin oxidation products, oxidative stress, and intracerebral hemorrhage" @default.
• W85585032 cites W12152619 @default.
• W85585032 cites W1534827720 @default.
• W85585032 cites W1563409492 @default.
• W85585032 cites W1964639517 @default.
• W85585032 cites W1970575337 @default.
• W85585032 cites W1971876814 @default.
• W85585032 cites W1977420171 @default.
• W85585032 cites W1977833357 @default.
• W85585032 cites W1993557217 @default.
• W85585032 cites W2006872818 @default.
• W85585032 cites W2030529426 @default.
• W85585032 cites W2035239697 @default.
• W85585032 cites W2038251576 @default.
• W85585032 cites W2042192966 @default.
• W85585032 cites W2042231981 @default.
• W85585032 cites W2053824414 @default.
• W85585032 cites W2055497119 @default.
• W85585032 cites W2070471389 @default.
• W85585032 cites W2083883672 @default.
• W85585032 cites W2104721556 @default.
• W85585032 cites W2109358726 @default.
• W85585032 cites W2113238081 @default.
• W85585032 cites W2117995382 @default.
• W85585032 cites W2169595519 @default.
• W85585032 cites W2171291238 @default.
• W85585032 cites W2284487392 @default.
• W85585032 cites W969915667 @default.
• W85585032 doi "https://doi.org/10.1007/978-3-211-09469-3_2" @default.
• W85585032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2765408" @default.
• W85585032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19066073" @default.
• W85585032 hasPublicationYear "2009" @default.
• W85585032 type Work @default.
• W85585032 sameAs 85585032 @default.
• W85585032 citedByCount "41" @default.
• W85585032 countsByYear W855850322012 @default.
• W85585032 countsByYear W855850322013 @default.
• W85585032 countsByYear W855850322014 @default.
• W85585032 countsByYear W855850322016 @default.
• W85585032 countsByYear W855850322018 @default.
• W85585032 countsByYear W855850322019 @default.
• W85585032 countsByYear W855850322020 @default.
• W85585032 countsByYear W855850322021 @default.
• W85585032 countsByYear W855850322022 @default.
• W85585032 countsByYear W855850322023 @default.
• W85585032 crossrefType "book-chapter" @default.
• W85585032 hasAuthorship W85585032A5006724619 @default.
• W85585032 hasAuthorship W85585032A5009866471 @default.
• W85585032 hasAuthorship W85585032A5021539455 @default.
• W85585032 hasAuthorship W85585032A5031142537 @default.
• W85585032 hasAuthorship W85585032A5055042810 @default.
• W85585032 hasAuthorship W85585032A5057605812 @default.
• W85585032 hasAuthorship W85585032A5082999475 @default.
• W85585032 hasBestOaLocation W855850322 @default.
• W85585032 hasConcept C126322002 @default.
• W85585032 hasConcept C141071460 @default.
• W85585032 hasConcept C150903083 @default.
• W85585032 hasConcept C178790620 @default.
• W85585032 hasConcept C185592680 @default.
• W85585032 hasConcept C207001950 @default.
• W85585032 hasConcept C2776151105 @default.
• W85585032 hasConcept C2777094939 @default.
• W85585032 hasConcept C2777513400 @default.
• W85585032 hasConcept C2777736543 @default.
• W85585032 hasConcept C2778401633 @default.
• W85585032 hasConcept C2778917026 @default.
• W85585032 hasConcept C2779662492 @default.
• W85585032 hasConcept C2910876585 @default.
• W85585032 hasConcept C42219234 @default.
• W85585032 hasConcept C533411734 @default.
• W85585032 hasConcept C55493867 @default.
• W85585032 hasConcept C71924100 @default.
• W85585032 hasConcept C77176794 @default.
• W85585032 hasConcept C86803240 @default.
• W85585032 hasConcept C98274493 @default.
• W85585032 hasConceptScore W85585032C126322002 @default.
• W85585032 hasConceptScore W85585032C141071460 @default.
• W85585032 hasConceptScore W85585032C150903083 @default.
• W85585032 hasConceptScore W85585032C178790620 @default.
• W85585032 hasConceptScore W85585032C185592680 @default.
• W85585032 hasConceptScore W85585032C207001950 @default.
• W85585032 hasConceptScore W85585032C2776151105 @default.
• W85585032 hasConceptScore W85585032C2777094939 @default.
• W85585032 hasConceptScore W85585032C2777513400 @default.
• W85585032 hasConceptScore W85585032C2777736543 @default.
• W85585032 hasConceptScore W85585032C2778401633 @default.
• W85585032 hasConceptScore W85585032C2778917026 @default.

• next