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- W8559032 abstract "Psoriasis is a chronic autoimmune disease of the skin that affects around 2% of the Caucasian population but is found worldwide in all populations. It has a strong negative impact on quality of life and can be associated with arthritis, which can be severe and deforming. The disease has a strong genetic component and tends to have a fluctuating course that can often be linked to environmental factors. In recent years, considerable progress has been made in unraveling the genetic complexity of psoriasis, mostly through the use of genome-wide association studies. At this time, over 20 genetic susceptibility loci have been identified. Most of these are immunologic in nature and broadly map into a few distinctive biological pathways: antigen processing and presentation, the T helper 1 cell and T helper 17 cell (Th1/Th17) inflammatory axes, epidermal function, tumor necrosis factor alpha (TNF-α) and nuclear factor kappa B (NF-κB) signaling, and dendritic cell and macrophage activation. Although it is foreseeable that this blueprint is going to become even more comprehensive with the elucidation of additional causative variants, we are now finally able to begin to understand how such a distinctive pattern of cutaneous inflammation develops in this fascinating yet enigmatic disease." @default.
- W8559032 created "2016-06-24" @default.
- W8559032 creator A5015004042 @default.
- W8559032 creator A5058475475 @default.
- W8559032 date "2013-01-01" @default.
- W8559032 modified "2023-09-24" @default.
- W8559032 title "Psoriasis" @default.
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