Matches in SemOpenAlex for { <https://semopenalex.org/work/W8559787> ?p ?o ?g. }
- W8559787 endingPage "210" @default.
- W8559787 startingPage "185" @default.
- W8559787 abstract "Dendritic cells (DCs) are essential for the initiation of an effective immune response. Despite this, our understanding of the molecular regulation of this important cell type has lagged significantly behind that of other lymphoid populations such as B and T cells, but recent development of various tools has greatly facilitated progress in the field. Here, we review the transcription factors that drive peripheral DC subset fate decisions. While Pu.1, Ikaros, and Gfi-1 are essential for precursor DCs to give rise to monocytes, conventional DCs, and plasmacytoid DCs, the balance between E2-2 and Id2 directs committed precursors along a pDC or cDC lineage, respectively. Several transcription factors such as Batf3, Nfil3, and Id2 are required for different DC subsets at steady-state and drive segregation into the individual DCs subsets late in development in the CD8 lineage. During inflammation, CD8-expressing DCs emerge that feature many of the hallmarks of classical CD8α+ DCs but surprisingly do not depend on the same transcription factors. Thus, the immune system has developed two pathways of DC differentiation that enable it to maintain homeostatic balance and to respond rapidly to the emergency requirement for DCs that might occur during infection." @default.
- W8559787 created "2016-06-24" @default.
- W8559787 creator A5062316238 @default.
- W8559787 creator A5077614342 @default.
- W8559787 date "2013-01-01" @default.
- W8559787 modified "2023-09-25" @default.
- W8559787 title "Terminal Differentiation of Dendritic Cells" @default.
- W8559787 cites W1512751723 @default.
- W8559787 cites W1525176639 @default.
- W8559787 cites W1787214439 @default.
- W8559787 cites W1900229962 @default.
- W8559787 cites W1925863651 @default.
- W8559787 cites W1950729478 @default.
- W8559787 cites W1963617750 @default.
- W8559787 cites W1964873147 @default.
- W8559787 cites W1965218665 @default.
- W8559787 cites W1965847911 @default.
- W8559787 cites W1966052560 @default.
- W8559787 cites W1968458512 @default.
- W8559787 cites W1977330771 @default.
- W8559787 cites W1981253936 @default.
- W8559787 cites W1981743414 @default.
- W8559787 cites W1985753010 @default.
- W8559787 cites W1987481383 @default.
- W8559787 cites W1989645452 @default.
- W8559787 cites W1994103354 @default.
- W8559787 cites W1997512963 @default.
- W8559787 cites W2001042507 @default.
- W8559787 cites W2001764493 @default.
- W8559787 cites W2002051393 @default.
- W8559787 cites W2004207939 @default.
- W8559787 cites W2004824087 @default.
- W8559787 cites W2005115869 @default.
- W8559787 cites W2006368636 @default.
- W8559787 cites W2006772331 @default.
- W8559787 cites W2008228521 @default.
- W8559787 cites W2010562798 @default.
- W8559787 cites W2018718597 @default.
- W8559787 cites W2020744692 @default.
- W8559787 cites W2030178793 @default.
- W8559787 cites W2030179905 @default.
- W8559787 cites W2035213168 @default.
- W8559787 cites W2038068026 @default.
- W8559787 cites W2045901162 @default.
- W8559787 cites W2046505430 @default.
- W8559787 cites W2048365283 @default.
- W8559787 cites W2048793063 @default.
- W8559787 cites W2051008724 @default.
- W8559787 cites W2052453105 @default.
- W8559787 cites W2054581136 @default.
- W8559787 cites W2059604791 @default.
- W8559787 cites W2061696866 @default.
- W8559787 cites W2063277895 @default.
- W8559787 cites W2065085347 @default.
- W8559787 cites W2065086280 @default.
- W8559787 cites W2065391646 @default.
- W8559787 cites W2067420339 @default.
- W8559787 cites W2068557660 @default.
- W8559787 cites W2074576643 @default.
- W8559787 cites W2074950512 @default.
- W8559787 cites W2076092191 @default.
- W8559787 cites W2076610281 @default.
- W8559787 cites W2079822769 @default.
- W8559787 cites W2080161843 @default.
- W8559787 cites W2080710417 @default.
- W8559787 cites W2081225723 @default.
- W8559787 cites W2081773622 @default.
- W8559787 cites W2082670705 @default.
- W8559787 cites W2083872083 @default.
- W8559787 cites W2088317975 @default.
- W8559787 cites W2090345691 @default.
- W8559787 cites W2091341060 @default.
- W8559787 cites W2094504570 @default.
- W8559787 cites W2094863064 @default.
- W8559787 cites W2096249856 @default.
- W8559787 cites W2096757412 @default.
- W8559787 cites W2100820895 @default.
- W8559787 cites W2101541399 @default.
- W8559787 cites W2101595031 @default.
- W8559787 cites W2105089699 @default.
- W8559787 cites W2105329191 @default.
- W8559787 cites W2105606708 @default.
- W8559787 cites W2108490725 @default.
- W8559787 cites W2108765339 @default.
- W8559787 cites W2113417184 @default.
- W8559787 cites W2113594480 @default.
- W8559787 cites W2113779347 @default.
- W8559787 cites W2114675972 @default.
- W8559787 cites W2115889659 @default.
- W8559787 cites W2119622948 @default.
- W8559787 cites W2121726659 @default.
- W8559787 cites W2122044177 @default.
- W8559787 cites W2122599803 @default.
- W8559787 cites W2122968144 @default.
- W8559787 cites W2123602250 @default.
- W8559787 cites W2126122040 @default.
- W8559787 cites W2127944870 @default.
- W8559787 cites W2128305305 @default.