FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W856261079> ?p ?o ?g. }

• W856261079 endingPage "e0003866" @default.
• W856261079 startingPage "e0003866" @default.
• W856261079 abstract "Leptospirosis occurs worldwide, but the global incidence of human disease and its mortality are not well understood. Many patients are undiagnosed and untreated due to its non-specific symptoms and a lack of access to diagnostics. This study systematically reviews the literature to clarify the mortality from untreated leptospirosis. Results will help quantify the global burden of disease and guide health policies.A comprehensive literature search was performed to identify untreated patient series. Included patients were symptomatic, but asymptomatic patients and those who had received antibiotics, dialysis or who were treated on Intensive Care Units were excluded. Included patients had a confirmed laboratory diagnosis by culture, PCR, or serological tests. Data was extracted and individual patient series were assessed for bias. Thirty-five studies, comprising 41 patient series and 3,390 patients, were included in the study. A high degree of bias within studies was shown due to limitations in study design, diagnostic tests and missing data. Median series mortality was 2.2% (Range 0.0-39.7%), but mortality was high in jaundiced patients (19.1%) (Range 0.0-39.7%), those with renal failure 12.1% (Range 0-25.0%) and in patients aged over 60 (60%) (Range 33.3-60%), but low in anicteric patients (0%) (Range 0-1.7%).This systematic review contributes to our understanding of the mortality of untreated leptospirosis and provides data for the estimation of DALYs attributable to this disease. We show that mortality is significantly higher in older patients with icteric disease or renal failure but is lower in younger, anicteric patients. Increased surveillance and accurate point-of-care diagnostics are required to better understand the incidence and improve diagnosis of disease. Empirical treatment strategies should prioritize early treatment to improve outcomes from leptospirosis." @default.
• W856261079 created "2016-06-24" @default.
• W856261079 creator A5013453998 @default.
• W856261079 creator A5016623634 @default.
• W856261079 creator A5087140749 @default.
• W856261079 date "2015-06-25" @default.
• W856261079 modified "2023-10-17" @default.
• W856261079 title "A Systematic Review of the Mortality from Untreated Leptospirosis" @default.
• W856261079 cites W1488433982 @default.
• W856261079 cites W1584654198 @default.
• W856261079 cites W1971362020 @default.
• W856261079 cites W1985640822 @default.
• W856261079 cites W1991776174 @default.
• W856261079 cites W2000407166 @default.
• W856261079 cites W2005817713 @default.
• W856261079 cites W2006737247 @default.
• W856261079 cites W2013064761 @default.
• W856261079 cites W2020018978 @default.
• W856261079 cites W2021308195 @default.
• W856261079 cites W2025222817 @default.
• W856261079 cites W2027180914 @default.
• W856261079 cites W2028389680 @default.
• W856261079 cites W2031718560 @default.
• W856261079 cites W2034435065 @default.
• W856261079 cites W2046511700 @default.
• W856261079 cites W2061340774 @default.
• W856261079 cites W2067191847 @default.
• W856261079 cites W2069070921 @default.
• W856261079 cites W2074123829 @default.
• W856261079 cites W2075096237 @default.
• W856261079 cites W2082166045 @default.
• W856261079 cites W2084522362 @default.
• W856261079 cites W2085914497 @default.
• W856261079 cites W2087568332 @default.
• W856261079 cites W2090318902 @default.
• W856261079 cites W2094305707 @default.
• W856261079 cites W2098483389 @default.
• W856261079 cites W2111885696 @default.
• W856261079 cites W2126795164 @default.
• W856261079 cites W2129107412 @default.
• W856261079 cites W2130831420 @default.
• W856261079 cites W2135517691 @default.
• W856261079 cites W2144728133 @default.
• W856261079 cites W2149825882 @default.
• W856261079 cites W2150075989 @default.
• W856261079 cites W2156429274 @default.
• W856261079 cites W2158445955 @default.
• W856261079 cites W2159058616 @default.
• W856261079 cites W2316238929 @default.
• W856261079 cites W2399333329 @default.
• W856261079 cites W2400388575 @default.
• W856261079 cites W2914206013 @default.
• W856261079 cites W3090390177 @default.
• W856261079 cites W4211105424 @default.
• W856261079 cites W4211128005 @default.
• W856261079 cites W4236020364 @default.
• W856261079 doi "https://doi.org/10.1371/journal.pntd.0003866" @default.
• W856261079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4482028" @default.
• W856261079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26110270" @default.
• W856261079 hasPublicationYear "2015" @default.
• W856261079 type Work @default.
• W856261079 sameAs 856261079 @default.
• W856261079 citedByCount "62" @default.
• W856261079 countsByYear W8562610792016 @default.
• W856261079 countsByYear W8562610792017 @default.
• W856261079 countsByYear W8562610792018 @default.
• W856261079 countsByYear W8562610792019 @default.
• W856261079 countsByYear W8562610792020 @default.
• W856261079 countsByYear W8562610792021 @default.
• W856261079 countsByYear W8562610792022 @default.
• W856261079 countsByYear W8562610792023 @default.
• W856261079 crossrefType "journal-article" @default.
• W856261079 hasAuthorship W856261079A5013453998 @default.
• W856261079 hasAuthorship W856261079A5016623634 @default.
• W856261079 hasAuthorship W856261079A5087140749 @default.
• W856261079 hasBestOaLocation W8562610791 @default.
• W856261079 hasConcept C107130276 @default.
• W856261079 hasConcept C120665830 @default.
• W856261079 hasConcept C121332964 @default.
• W856261079 hasConcept C126322002 @default.
• W856261079 hasConcept C142724271 @default.
• W856261079 hasConcept C177713679 @default.
• W856261079 hasConcept C179755657 @default.
• W856261079 hasConcept C187212893 @default.
• W856261079 hasConcept C2777910003 @default.
• W856261079 hasConcept C2778033228 @default.
• W856261079 hasConcept C2779134260 @default.
• W856261079 hasConcept C2779978075 @default.
• W856261079 hasConcept C61511704 @default.
• W856261079 hasConcept C71924100 @default.
• W856261079 hasConceptScore W856261079C107130276 @default.
• W856261079 hasConceptScore W856261079C120665830 @default.
• W856261079 hasConceptScore W856261079C121332964 @default.
• W856261079 hasConceptScore W856261079C126322002 @default.
• W856261079 hasConceptScore W856261079C142724271 @default.
• W856261079 hasConceptScore W856261079C177713679 @default.
• W856261079 hasConceptScore W856261079C179755657 @default.
• W856261079 hasConceptScore W856261079C187212893 @default.

• next