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- W856288181 abstract "Capacity to perform prolonged exercise is reduced in high ambient temperatures, butthis premature fatigue is not adequately explained by peripheral mechanisms. The aimof this thesis was to examine some possible underlying mechanisms of central fatigueoperating during prolonged exercise in a warm environment.The first series of experiments investigated the effect of nutritional manipulation ofcentral serotonergic activity through alterations to the plasma concentration ratio offree-tryptophan to branched-chain amino acids (f-TRP:BCAA). In contrast toprevious reports, acute BCAA supplementation failed to alter perceived exertion anddelay the onset of fatigue (Chapter 3). This response was similar when exercise waspreceded by an exercise and diet regimen designed to reduce glycogen availability(Chapter 4). The ingestion of meals containing added carbohydrate and fat did notalter f-TRP:BCAA at rest (Chapter 5). Acute dopaminergic / noradrenergic reuptake inhibition with bupropion increasedexercise perfonnance by 9 % in warm conditions (30C), but this effect was notapparent at 18C (Chapter 6). This response was accompanied by attainment of ahigher core temperature and heart rate towards the end of the bupropion trial in theheat despite no detectable difference in perceived exertion and thermal stress. Thesedata suggested that maintenance of catecholaminergic activity may dampen inhibitorysignals from the CNS due to the attainment of a high core temperature, allowingpower output to be maintained.The blood-brain barrier (BBB) regulates the exchange of substances between thecerebral interstitial fluid and the blood to maintain a stable environment for the CNS.If the BBB is compromised this may adversely influence nonnal brain function.Serum S1OOb, a proposed peripheral marker of BBB penneability, was increasedfollowing exercise in a warm environment (Chapter 7). These data indicate thatexposure to combined exercise and heat stress may result in a loss of BBB integrity." @default.
- W856288181 created "2016-06-24" @default.
- W856288181 creator A5029844979 @default.
- W856288181 date "2005-01-01" @default.
- W856288181 modified "2023-09-24" @default.
- W856288181 title "Possible neurobiological mechanisms of fatigue during prolonged exercise in a warm environment." @default.
- W856288181 hasPublicationYear "2005" @default.
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