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- W856652016 abstract "Objective:To investigate the hepatitis B virus genotypes and the natural mutation of HBV YMDD motif in the patiens with chronic hepatitis B who were not treated with lamivudine and to observe the relationship between the YMDD natural mutation and the hepatitis B virus genotypes.Methods:Enzyme linked immuno sorbent assay(ELISA)was used to test HBV markers.The natural mutation of HBV YMDD motif and HBV virus genotypes was detected by PCR and reverse dot blot in 49 patients with chronic hepatitis B.Results:Among the 49 patients,8(16.33%)were genotype B,34(69.39%)were genotype C.Of the 49 patients,6 were detected to be YMDD mutants,the rate of YMDD mutant was 17.65%.No significant difference of YMDD mutant was found between patients with genotype B and C(P0.05).The same result occurred for HBV markers between them(P0.05).Conclusion:Genotype C is the dominant genotype of HBV in this area.There is no significant difference of HBV YMDD mutation between genotype B and C." @default.
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- W856652016 date "2009-01-01" @default.
- W856652016 modified "2023-09-23" @default.
- W856652016 title "Correlations between hepatitis B virus genotypes and natural mutation of YMDD in Hainan" @default.
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