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- W85686722 abstract "Abstract CD4+ T cell vaccine has less been studied. In this study, we demonstrated that active CD4+ T (aT) cells with uptake of ovalbumin (OVA)-pulsed dendritic cell (DCova)-derived exosome (EXOova) express exosomal peptide/major histocompetibility complex (pMHC) I and costimulatory molecules. EXOova-uptaken (targeted) CD4+ aT (aTexo) cells can stimulate central memory CD8+ cytotoxic T lymphocyte (CTL) responses, more efficient in vivo antitumor immunity and long-term CD8+ T cell memory responses than DCova, and break the self immune tolerance in two transgenic mouse models leading to OVA- and neu-specific CTL-mediated diabetes and antitumor, respectively. We further elucidated that aTEXO’s stimulatory effect is mediated via its IL-2 secretion and acquired CD80 costimulation, and specifically targeted to CD8+ T cells in vivo via acquired pMHC I complexes. Therefore, EXO-targeted CD4+ T cell vaccine may represent a novel and highly effective vaccine strategy for inducing immune responses against not only tumors, but also other infectious diseases. Therefore, EXO-targeted CD4+ T cell vaccine may represent a novel effective vaccine strategy for therapeutic treatment of patients with early stage of HER-2-positive or trastuzumab-resistant HER-2-positive breast cancers, and for adjuvant treatment of patients with potential risk of metastasis after surgical treatment." @default.
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- W85686722 date "2011-04-01" @default.
- W85686722 modified "2023-09-23" @default.
- W85686722 title "A novel HER-2-specific exosome-targeted T cell-based vaccine: immunotherapy of established lung metastasis in transgenic HLA-A2/HER-2 mice (155.37)" @default.
- W85686722 doi "https://doi.org/10.4049/jimmunol.186.supp.155.37" @default.
- W85686722 hasPublicationYear "2011" @default.
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