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- W8569657 abstract "Deletion of 16q (del(16q)) has been identified in 15% of newlydiagnosed myeloma but the prognostic impact has not beendetermined. We performed FISH on CD138 selected plasma cellsfrom 861 newly diagnosed patients with multiple myeloma from theLRF UK Myeloma Forum Cytogenetics Database. Del(16q) occurredin 168/861 cases (19.5%) and was significantly associated withdeletion 13q (54.8% vs 43.5%, P50.009), deletion of IgH (19.6% vs8.7%, Po0.001), deletion 17p (20.7% vs 7.2%, Po0.001) and nonhyperdiploidstatus (47.9% vs 40.3%, P50.043). Clinical andsurvival data was available in 505 patients. Median age was 65 years(range 33–92) and median follow-up was 19 months. Del(16q) showedno association with baseline clinical and demographic parametersbut was associated with a significantly worse overall survival (mediansurvival 36 months vs not reached, P50.025). Moreover, del(16q)conferred additional adverse impact in combination with the knownpoor risk cytogenetic factors t(4;14) and deletion 17p (del(17p)).Median survival for del(16q) and t(4;14) was 13 months, del (16q)alone 36 months, t(4;14) alone not reached, P50.001. Mediansurvival for del(16q) and del(17p) was 17 months, del(16q) alone 36months, del(17p) alone not reached, P50.003. Multivariate analysisconfirmed that del(16q) retained independence as an adverseprognostic marker (P50.003) along with t(4;14), t(14;16), light chainisotype, WHO performance status, ISS and age. Integration of gene mapping with global gene expression data in asubset of 55 cases identified two potential tumour suppressor geneslocated on 16q, CYLD and WWOX. We have shown that loss of CYLDdysregulates the NFkB pathway and loss of WWOX dysregulates apoptosisvia p73, both of crucial importance in myeloma biology. WWOX isalso a common fragile site gene and deletions at other common fragilesites were identified that may also contribute to myeloma pathogenesis.An update of this mapping and expression data including the NFkBsignature associated with 16q deletion will be presented." @default.
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- W8569657 date "2007-04-17" @default.
- W8569657 modified "2023-09-27" @default.
- W8569657 title "Deletion of 16q identified by FISH is an independent adverse prognostic marker in multiple myeloma" @default.
- W8569657 hasPublicationYear "2007" @default.
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