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• W85747335 abstract "Publisher Summary This chapter provides an overview of the clinical features of postherpetic neuralgia (PHN) and emphasizes guidelines for management of the same. PHN is a common cause of neuropathic pain. There is no known panacea for patients with PHN; the pain is ameliorated by treatment in many patients as well as improving with time. PHN is a consequence of herpes zoster (HZ), which is caused by re-activation of the varicella zoster virus (VZV) usually contracted in childhood. In the course of the illness it is presumed to enter sensory nerve fibers and to be transported to the trigeminal, geniculate, and dorsal root ganglia where it comes to be dormant for many years; the virus may re-erupt in the sensory ganglion because of declining immune surveillance accompanying advancing age. The management of PHN remains, in some cases, an intractable problem. Though the prevention of PHN remains difficult, a reasonable regimen could be administration of 60 mg prednisone on diagnosis, with reduction being implemented over 10–14 days. For established PHN there is firm support for the reduction of pain from severe to mild in two-thirds of patients by the use of low doses of amitriptyline with gradual, small increments." @default.
• W85747335 created "2016-06-24" @default.
• W85747335 creator A5024614022 @default.
• W85747335 date "1990-01-01" @default.
• W85747335 modified "2023-09-27" @default.
• W85747335 title "Postherpetic neuralgia: clinical features and treatment" @default.
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• W85747335 doi "https://doi.org/10.1016/b978-0-407-01124-3.50015-0" @default.
• W85747335 hasPublicationYear "1990" @default.
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