Matches in SemOpenAlex for { <https://semopenalex.org/work/W85752841> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W85752841 endingPage "4" @default.
- W85752841 startingPage "1322" @default.
- W85752841 abstract "The study was aimed at determining the effect of Coca-Cola on the pharmacokinetics of ibuprofen in rabbits. In a cross-over study, ibuprofen was given orally in a dose of 56 mg/kg, prepared as 0.5% suspension in carboxymethyl cellulose (CMC) and blood samples (1 ml) were drawn at different time intervals from 0-12 hr. After a washout period of 7 days, Coca-Cola in a dose of (5 ml/kg) was administered along with ibuprofen (56 mg/kg) and blood samples were drawn from 0-12 hr. To these rabbits, 5 ml/kg Coca-Cola was administered once daily for another 7 days. On 8th day, Coca-Cola (5 ml/kg) along with ibuprofen (56 mg/kg), prepared as a suspension was administered and blood samples (1 ml each) were drawn at similar time intervals. Plasma was separated and assayed for ibuprofen by HPLC technique and various pharmacokinetic parameters were calculated. The Cmax and AUC0-alpha of ibuprofen were significantly increased after single and multiple doses of Coca-Cola, thereby indicating increased extent of absorption of ibuprofen. The results warrant the reduction of ibuprofen daily dosage, frequency when administered with Coca-Cola." @default.
- W85752841 created "2016-06-24" @default.
- W85752841 creator A5048157874 @default.
- W85752841 creator A5081086213 @default.
- W85752841 date "2003-11-01" @default.
- W85752841 modified "2023-09-26" @default.
- W85752841 title "Influence of acidic beverage (Coca-Cola) on pharmacokinetics of ibuprofen in healthy rabbits." @default.
- W85752841 cites W2051508505 @default.
- W85752841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15332505" @default.
- W85752841 hasPublicationYear "2003" @default.
- W85752841 type Work @default.
- W85752841 sameAs 85752841 @default.
- W85752841 citedByCount "4" @default.
- W85752841 countsByYear W857528412015 @default.
- W85752841 countsByYear W857528412019 @default.
- W85752841 crossrefType "journal-article" @default.
- W85752841 hasAuthorship W85752841A5048157874 @default.
- W85752841 hasAuthorship W85752841A5081086213 @default.
- W85752841 hasConcept C112698675 @default.
- W85752841 hasConcept C112705442 @default.
- W85752841 hasConcept C126322002 @default.
- W85752841 hasConcept C140793950 @default.
- W85752841 hasConcept C144133560 @default.
- W85752841 hasConcept C185592680 @default.
- W85752841 hasConcept C22979827 @default.
- W85752841 hasConcept C2779944601 @default.
- W85752841 hasConcept C2781138811 @default.
- W85752841 hasConcept C2992358082 @default.
- W85752841 hasConcept C43617362 @default.
- W85752841 hasConcept C71924100 @default.
- W85752841 hasConcept C86803240 @default.
- W85752841 hasConcept C98274493 @default.
- W85752841 hasConceptScore W85752841C112698675 @default.
- W85752841 hasConceptScore W85752841C112705442 @default.
- W85752841 hasConceptScore W85752841C126322002 @default.
- W85752841 hasConceptScore W85752841C140793950 @default.
- W85752841 hasConceptScore W85752841C144133560 @default.
- W85752841 hasConceptScore W85752841C185592680 @default.
- W85752841 hasConceptScore W85752841C22979827 @default.
- W85752841 hasConceptScore W85752841C2779944601 @default.
- W85752841 hasConceptScore W85752841C2781138811 @default.
- W85752841 hasConceptScore W85752841C2992358082 @default.
- W85752841 hasConceptScore W85752841C43617362 @default.
- W85752841 hasConceptScore W85752841C71924100 @default.
- W85752841 hasConceptScore W85752841C86803240 @default.
- W85752841 hasConceptScore W85752841C98274493 @default.
- W85752841 hasIssue "11" @default.
- W85752841 hasLocation W857528411 @default.
- W85752841 hasOpenAccess W85752841 @default.
- W85752841 hasPrimaryLocation W857528411 @default.
- W85752841 hasRelatedWork W141135543 @default.
- W85752841 hasRelatedWork W1981506382 @default.
- W85752841 hasRelatedWork W2006764019 @default.
- W85752841 hasRelatedWork W2009061198 @default.
- W85752841 hasRelatedWork W2027399993 @default.
- W85752841 hasRelatedWork W2045135299 @default.
- W85752841 hasRelatedWork W2064373593 @default.
- W85752841 hasRelatedWork W2071694141 @default.
- W85752841 hasRelatedWork W2081658199 @default.
- W85752841 hasRelatedWork W2092954825 @default.
- W85752841 hasRelatedWork W2118999453 @default.
- W85752841 hasRelatedWork W2129775766 @default.
- W85752841 hasRelatedWork W2153800799 @default.
- W85752841 hasRelatedWork W2352998524 @default.
- W85752841 hasRelatedWork W2363243212 @default.
- W85752841 hasRelatedWork W2372190597 @default.
- W85752841 hasRelatedWork W2392240787 @default.
- W85752841 hasRelatedWork W2401080248 @default.
- W85752841 hasRelatedWork W2419623734 @default.
- W85752841 hasRelatedWork W2777807315 @default.
- W85752841 hasVolume "41" @default.
- W85752841 isParatext "false" @default.
- W85752841 isRetracted "false" @default.
- W85752841 magId "85752841" @default.
- W85752841 workType "article" @default.