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- W857564341 abstract "CD4Foxp3 regulatory T cells (Tregs) are crucial in controlling immunity and self-tolerance. Consequently, in transplantation, Tregs play a central role in inhibiting acute rejection and promoting allograft tolerance. A more complete understanding of Treg biology may lead to novel therapeutic approaches to enhance Treg numbers and function.The maintenance of self-tolerance in nonlymphoid tissues requires the differentiation of Tregs in secondary lymphoid organs from naïve-like central Tregs into effector Tregs. Antigen and environmental cues guide this Treg differentiation, which parallels the types of adaptive immune responses taking place, allowing them to enter and function within specific nonlymphoid tissues. In addition to controlling inflammation, tissue-infiltrating Tregs unexpectedly regulate nonimmune processes, including metabolic homeostasis and tissue repair. Finally, Tregs can be directly and specifically targeted in vivo to augment their numbers or enhance their function in both secondary lymphoid organs and nonlymphoid tissues.Tregs exhibit a previously unrecognized breadth of function, which includes tissue-specific specialization and the regulation of both immune and nonimmune processes. This is of particular importance in transplantation since allo-reactive memory T cells can act directly within the allograft. Thus, therapeutic approaches may need to promote Treg function in transplanted tissue, as well as in secondary lymphoid organs. Such therapy would not only prevent inflammation and acute rejection, but may also promote nonimmune processes within the allograft such as tissue homeostasis and repair." @default.
- W857564341 created "2016-06-24" @default.
- W857564341 creator A5005488593 @default.
- W857564341 creator A5068983783 @default.
- W857564341 date "2015-08-01" @default.
- W857564341 modified "2023-10-09" @default.
- W857564341 title "New insights into the mechanisms of Treg function" @default.
- W857564341 cites W1511438228 @default.
- W857564341 cites W1518244351 @default.
- W857564341 cites W1541810537 @default.
- W857564341 cites W1643655877 @default.
- W857564341 cites W1947330042 @default.
- W857564341 cites W1967278561 @default.
- W857564341 cites W1967782952 @default.
- W857564341 cites W1969613993 @default.
- W857564341 cites W1971079822 @default.
- W857564341 cites W1972263413 @default.
- W857564341 cites W1978073168 @default.
- W857564341 cites W1981690705 @default.
- W857564341 cites W1985649568 @default.
- W857564341 cites W1987735044 @default.
- W857564341 cites W1988181665 @default.
- W857564341 cites W1996642272 @default.
- W857564341 cites W1998603634 @default.
- W857564341 cites W2007631222 @default.
- W857564341 cites W2010957046 @default.
- W857564341 cites W2011873300 @default.
- W857564341 cites W2012628829 @default.
- W857564341 cites W2014540704 @default.
- W857564341 cites W2016191219 @default.
- W857564341 cites W2027581425 @default.
- W857564341 cites W2029640857 @default.
- W857564341 cites W2036383793 @default.
- W857564341 cites W2041544510 @default.
- W857564341 cites W2050570363 @default.
- W857564341 cites W2060637301 @default.
- W857564341 cites W2061975642 @default.
- W857564341 cites W2068392572 @default.
- W857564341 cites W2072509185 @default.
- W857564341 cites W2073045132 @default.
- W857564341 cites W2077490433 @default.
- W857564341 cites W2080935386 @default.
- W857564341 cites W2082957436 @default.
- W857564341 cites W2088547934 @default.
- W857564341 cites W2093135504 @default.
- W857564341 cites W2101336470 @default.
- W857564341 cites W2102377692 @default.
- W857564341 cites W2102650038 @default.
- W857564341 cites W2102771148 @default.
- W857564341 cites W2104049583 @default.
- W857564341 cites W2104959557 @default.
- W857564341 cites W2107111117 @default.
- W857564341 cites W2117614250 @default.
- W857564341 cites W2119860862 @default.
- W857564341 cites W2125676014 @default.
- W857564341 cites W2125921975 @default.
- W857564341 cites W2126468249 @default.
- W857564341 cites W2132427916 @default.
- W857564341 cites W213324783 @default.
- W857564341 cites W2136129817 @default.
- W857564341 cites W2141649011 @default.
- W857564341 cites W2143417567 @default.
- W857564341 cites W2143676542 @default.
- W857564341 cites W2144147645 @default.
- W857564341 cites W2148226248 @default.
- W857564341 cites W2148618469 @default.
- W857564341 cites W2149142511 @default.
- W857564341 cites W2151328705 @default.
- W857564341 cites W2153389047 @default.
- W857564341 cites W2153550772 @default.
- W857564341 cites W2155521069 @default.
- W857564341 cites W2156067155 @default.
- W857564341 cites W2160167330 @default.
- W857564341 cites W2160311765 @default.
- W857564341 cites W2165336179 @default.
- W857564341 cites W2167327834 @default.
- W857564341 cites W2169032921 @default.
- W857564341 cites W2169800587 @default.
- W857564341 cites W2169859344 @default.
- W857564341 cites W2170190655 @default.
- W857564341 cites W2172137324 @default.
- W857564341 cites W2792966232 @default.
- W857564341 cites W4242872472 @default.
- W857564341 doi "https://doi.org/10.1097/mot.0000000000000212" @default.
- W857564341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4575588" @default.
- W857564341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26126193" @default.
- W857564341 hasPublicationYear "2015" @default.
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