Matches in SemOpenAlex for { <https://semopenalex.org/work/W857649061> ?p ?o ?g. }
- W857649061 abstract "Exercise is often prescribed for patients with chronic pain, but there is little objective evidence supporting this recommendation. Therefore, we tested the effect of moderate aerobic exercise on the sensory hypersensitivity produced in an animal model of neuropathic pain. Male rats that underwent unilateral ligation of the L5 and L6 spinal nerves (SNL) were divided into exercise-trained or sedentary groups. Exercise training was performed using a treadmill, beginning 7 days after surgery, and continued 5 days a week for 5 weeks. Animals were exercised 30 min/day, at a speed of 14-16 m/min. Sensory testing was performed 23 hours after exercise training. Typical thermal and tactile hypersensitivity developed within 1 week after surgery. Treadmill training reversed thermal and tactile hypersensitivity in injured animals within 4 weeks, but had no effect on sham-operated or non-operated animals. One week after the cessation of exercise training, tactile hypersensitivity returned. The effects of exercise training on SNL-induced sensory hypersensitivity were reversed by the opioid receptor antagonist naloxone. Naloxone or naloxone methiodide reversed the effects of exercise when administered intracerebroventricularly (i.c.v.). Immunohistochemistry revealed increased immunostaining for β-endorphin and metenkephalin in the periaquaductal grey (PAG) and rostral ventromedial medulla (RVM) regions of exercise-trained animals compared to sedentary animals. An ELISA immunoassay revealed a 31% increase in PAG β-endorphin content in exercise-trained SNL animals. More BDNF was also present in the brain’s of exercise-trained animals" @default.
- W857649061 created "2016-06-24" @default.
- W857649061 creator A5002239223 @default.
- W857649061 date "2007-01-01" @default.
- W857649061 modified "2023-09-24" @default.
- W857649061 title "Reversal of neuropathic pain with exercise is mediated by endogenous opioids" @default.
- W857649061 cites W1504527804 @default.
- W857649061 cites W1547720366 @default.
- W857649061 cites W1612950486 @default.
- W857649061 cites W1840804593 @default.
- W857649061 cites W1964037009 @default.
- W857649061 cites W1965066118 @default.
- W857649061 cites W1965866432 @default.
- W857649061 cites W1969254522 @default.
- W857649061 cites W1970281228 @default.
- W857649061 cites W1970516662 @default.
- W857649061 cites W1972510628 @default.
- W857649061 cites W1976037358 @default.
- W857649061 cites W1978019127 @default.
- W857649061 cites W1979143816 @default.
- W857649061 cites W1979360698 @default.
- W857649061 cites W1979639875 @default.
- W857649061 cites W1982095811 @default.
- W857649061 cites W1982941186 @default.
- W857649061 cites W1985260834 @default.
- W857649061 cites W1989605260 @default.
- W857649061 cites W1993895973 @default.
- W857649061 cites W1998388691 @default.
- W857649061 cites W1999190561 @default.
- W857649061 cites W2003327922 @default.
- W857649061 cites W2003962476 @default.
- W857649061 cites W2011195852 @default.
- W857649061 cites W2014007136 @default.
- W857649061 cites W2018491433 @default.
- W857649061 cites W2018756779 @default.
- W857649061 cites W2019544116 @default.
- W857649061 cites W2019946314 @default.
- W857649061 cites W2020850305 @default.
- W857649061 cites W2021551531 @default.
- W857649061 cites W2022974680 @default.
- W857649061 cites W2026156481 @default.
- W857649061 cites W2026796211 @default.
- W857649061 cites W2028010613 @default.
- W857649061 cites W2028243509 @default.
- W857649061 cites W2029122808 @default.
- W857649061 cites W2029856705 @default.
- W857649061 cites W2030777873 @default.
- W857649061 cites W2031113662 @default.
- W857649061 cites W2034457001 @default.
- W857649061 cites W2034775655 @default.
- W857649061 cites W2034858091 @default.
- W857649061 cites W2035853851 @default.
- W857649061 cites W2036234078 @default.
- W857649061 cites W2038990149 @default.
- W857649061 cites W2039106853 @default.
- W857649061 cites W2041331466 @default.
- W857649061 cites W2042090155 @default.
- W857649061 cites W2042415483 @default.
- W857649061 cites W2042575337 @default.
- W857649061 cites W2042936248 @default.
- W857649061 cites W2043724056 @default.
- W857649061 cites W2045017264 @default.
- W857649061 cites W2049374216 @default.
- W857649061 cites W2051535425 @default.
- W857649061 cites W2055051732 @default.
- W857649061 cites W2058005962 @default.
- W857649061 cites W2058020736 @default.
- W857649061 cites W2058334887 @default.
- W857649061 cites W2063342143 @default.
- W857649061 cites W2063478259 @default.
- W857649061 cites W2064823101 @default.
- W857649061 cites W2065033195 @default.
- W857649061 cites W2065546153 @default.
- W857649061 cites W2065969029 @default.
- W857649061 cites W2066120052 @default.
- W857649061 cites W2066191550 @default.
- W857649061 cites W2066362290 @default.
- W857649061 cites W2067924690 @default.
- W857649061 cites W2070091065 @default.
- W857649061 cites W2071546935 @default.
- W857649061 cites W2077547311 @default.
- W857649061 cites W2077764660 @default.
- W857649061 cites W2079841860 @default.
- W857649061 cites W2082959988 @default.
- W857649061 cites W2086021531 @default.
- W857649061 cites W2087506940 @default.
- W857649061 cites W2087672059 @default.
- W857649061 cites W2087859406 @default.
- W857649061 cites W2093778276 @default.
- W857649061 cites W2095639798 @default.
- W857649061 cites W2115819911 @default.
- W857649061 cites W2118663281 @default.
- W857649061 cites W2121651624 @default.
- W857649061 cites W2122586715 @default.
- W857649061 cites W2123134015 @default.
- W857649061 cites W2123856483 @default.
- W857649061 cites W2127057252 @default.
- W857649061 cites W2129652475 @default.
- W857649061 cites W2129991279 @default.
- W857649061 cites W2131110619 @default.