Matches in SemOpenAlex for { <https://semopenalex.org/work/W857782007> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W857782007 abstract "A transplantable murine colon adenocarcinoma (MAC16) was utilised as a model of human cancer cachexia. This tumour has been found to produce extensive weight loss, characterised by depletion of host body protein and lipid stores at a small tumour burden. This weight loss has been found to be associated with production by the tumour of a lipolytic factor, activity of which was inhibited in vitro by the polyunsaturated fatty acid (PUFA) eicosapentaenoic acid (EPA). EPA has also been shown to possess anti-tumour and anti-cachectic activity in vivo, leading to the hypothesis that fatty acids mobilised by the lipolytic factor supply a growth requirement of the MAC16 tumour. In this study mobilisation and sequestration of fatty acids by the tumour was found to be non-specific, although a relationship between weight loss and arachidonic acid (AA) concentration was found in both tumour-bearing mice, and human cancer patients. The anti-tumour effect of EPA, which was found to be associated with an increase in cell loss, but not its anti-cachectic activity, was reversed by the administration of the PUFAs oleic acid (OA) and linoleic acid (LA). LA was also found to be capable of stimulating tumour growth. Inhibition of either the cyclooxygenase or lipoxygenase pathways was found to result in reduction of tumour growth, leading to the implication of one of the metabolites of LA or AA in tumour growth and cachexia. The ethyl ester of EPA was found to be inactive against the growth and cachexia of the MAC16 tumour, due to its retarded uptake compared with the free acid. The anti-proliferative agent 5-fluorouracil was found to cause tumour growth inhibition, and when given in combination with EPA, reduced the phase of tumour regrowth observed after 4 to 5 days of treatment with EPA." @default.
- W857782007 created "2016-06-24" @default.
- W857782007 creator A5008149024 @default.
- W857782007 date "1993-09-01" @default.
- W857782007 modified "2023-09-28" @default.
- W857782007 title "Polyunsaturated fatty acids in tumour-induced cachexia" @default.
- W857782007 hasPublicationYear "1993" @default.
- W857782007 type Work @default.
- W857782007 sameAs 857782007 @default.
- W857782007 citedByCount "0" @default.
- W857782007 crossrefType "dissertation" @default.
- W857782007 hasAuthorship W857782007A5008149024 @default.
- W857782007 hasConcept C121608353 @default.
- W857782007 hasConcept C126322002 @default.
- W857782007 hasConcept C134018914 @default.
- W857782007 hasConcept C150903083 @default.
- W857782007 hasConcept C181199279 @default.
- W857782007 hasConcept C185592680 @default.
- W857782007 hasConcept C19038510 @default.
- W857782007 hasConcept C207001950 @default.
- W857782007 hasConcept C2776091944 @default.
- W857782007 hasConcept C2777704314 @default.
- W857782007 hasConcept C2778078955 @default.
- W857782007 hasConcept C2779689624 @default.
- W857782007 hasConcept C2780809830 @default.
- W857782007 hasConcept C2780857362 @default.
- W857782007 hasConcept C511355011 @default.
- W857782007 hasConcept C543025807 @default.
- W857782007 hasConcept C544821477 @default.
- W857782007 hasConcept C55493867 @default.
- W857782007 hasConcept C71924100 @default.
- W857782007 hasConcept C86803240 @default.
- W857782007 hasConceptScore W857782007C121608353 @default.
- W857782007 hasConceptScore W857782007C126322002 @default.
- W857782007 hasConceptScore W857782007C134018914 @default.
- W857782007 hasConceptScore W857782007C150903083 @default.
- W857782007 hasConceptScore W857782007C181199279 @default.
- W857782007 hasConceptScore W857782007C185592680 @default.
- W857782007 hasConceptScore W857782007C19038510 @default.
- W857782007 hasConceptScore W857782007C207001950 @default.
- W857782007 hasConceptScore W857782007C2776091944 @default.
- W857782007 hasConceptScore W857782007C2777704314 @default.
- W857782007 hasConceptScore W857782007C2778078955 @default.
- W857782007 hasConceptScore W857782007C2779689624 @default.
- W857782007 hasConceptScore W857782007C2780809830 @default.
- W857782007 hasConceptScore W857782007C2780857362 @default.
- W857782007 hasConceptScore W857782007C511355011 @default.
- W857782007 hasConceptScore W857782007C543025807 @default.
- W857782007 hasConceptScore W857782007C544821477 @default.
- W857782007 hasConceptScore W857782007C55493867 @default.
- W857782007 hasConceptScore W857782007C71924100 @default.
- W857782007 hasConceptScore W857782007C86803240 @default.
- W857782007 hasLocation W8577820071 @default.
- W857782007 hasOpenAccess W857782007 @default.
- W857782007 hasPrimaryLocation W8577820071 @default.
- W857782007 hasRelatedWork W1980594954 @default.
- W857782007 hasRelatedWork W1983107632 @default.
- W857782007 hasRelatedWork W1988300812 @default.
- W857782007 hasRelatedWork W1989812164 @default.
- W857782007 hasRelatedWork W2002691747 @default.
- W857782007 hasRelatedWork W2007588012 @default.
- W857782007 hasRelatedWork W2009857094 @default.
- W857782007 hasRelatedWork W2013751321 @default.
- W857782007 hasRelatedWork W2038405737 @default.
- W857782007 hasRelatedWork W2064330801 @default.
- W857782007 hasRelatedWork W2067580224 @default.
- W857782007 hasRelatedWork W2082357740 @default.
- W857782007 hasRelatedWork W2083086854 @default.
- W857782007 hasRelatedWork W2087902115 @default.
- W857782007 hasRelatedWork W2087978631 @default.
- W857782007 hasRelatedWork W2089641881 @default.
- W857782007 hasRelatedWork W2114848027 @default.
- W857782007 hasRelatedWork W2132077678 @default.
- W857782007 hasRelatedWork W2153210797 @default.
- W857782007 hasRelatedWork W330993904 @default.
- W857782007 isParatext "false" @default.
- W857782007 isRetracted "false" @default.
- W857782007 magId "857782007" @default.
- W857782007 workType "dissertation" @default.