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• W85783883 endingPage "129" @default.
• W85783883 startingPage "111" @default.
• W85783883 abstract "Publisher Summary This chapter summarizes what is known about one specific gene family acting in transcriptional control and pattern formation in vertebrate and invertebrate hearts: the NK-2 class of homeodomain factors. It is found that frog Nkx2.5 is expressed in a region much broader than that occupied by the definitive heart progenitors, in a pattern resembling that of the morphogenetic field mapped in other amphibia. Thus, the regulatory ability of the field may be limited to the zone of Nkx2.5 expression. On the other hand, loss of regulatory ability in the field occurs in advance of the loss of the Nkx2.5 expression. In the fish, two NK-2 genes—nkx2.5 and nkx2. 7—are expressed in different but overlapping domains in a region encompassing the heart field. nkx2.5 expression occurs in those cells definitively fated to the heart but also extends more caudally beyond the heart field into cells that will never participate in heart development, even if definitive progenitors are killed by laser ablation. The notochord may provide inhibitory signals, which keep cells in the caudal region from differentiating as heart. Cells that participate in regulation have been mapped to the cranial region of the heart field, and these cells express nkx2.7 but not nkx2.5. The findings are consistent with the view that heart potency in the morphogenetic field requires the presence of a cardiac Nkx2 gene, but that other positive and negative interactions determine the actual extent of the definitive progenitors and of the field itself. Ectopic expression of Nkx2.5 in frog and fish embryos, achieved by microinjection of Nkx2.5 mRNA into fertilized eggs, leads to larger hearts and myocardial hyperplasia, without ectopic activation of the myogenic program." @default.
• W85783883 created "2016-06-24" @default.
• W85783883 creator A5005923545 @default.
• W85783883 creator A5038651475 @default.
• W85783883 creator A5074383185 @default.
• W85783883 date "1999-01-01" @default.
• W85783883 modified "2023-10-14" @default.
• W85783883 title "Transcriptional Control and Pattern Formation in the Developing Vertebrate Heart" @default.
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