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- W85812278 abstract "The mature 3′ ends of nearly all eukaryotic messenger RNAs (mRNAs) are created by a two-step reaction that involves an endonucleolytic cleavage of the precursor-mRNA (pre-mRNA), followed by addition of a polyadenylate tail onto the upstream cleavage product. This relatively simple reaction requires numerous trans -acting protein factors that are directed to the correct cleavage site by cis -acting sequence elements within the pre-mRNA. The core molecular machinery responsible for 3′ end formation in mammals includes four multi-subunit protein complexes: cleavage and polyadenylation specificity factor, cleavage stimulation factor, cleavage factor I, and cleavage factor II, as well as the single subunit poly(A) polymerase. Today, we know that many more proteins are involved in the fine-tuning of the process, and several of these are thought to mediate cross talk between pre-mRNA maturation and other nuclear events. Even though each step of gene expression, such as transcription, capping, splicing, and 3′ end formation, can be reconstituted independently in in vitro systems, it is becoming increasingly evident that in vivo all these processes are coupled and dependent on each other. The correct processing of the 3′ end of pre-mRNA is crucial for gene expression, and defects in this reaction can greatly affect cell viability and growth." @default.
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- W85812278 date "2013-01-01" @default.
- W85812278 modified "2023-10-17" @default.
- W85812278 title "mRNA Polyadenylation in Eukaryotes" @default.
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- W85812278 doi "https://doi.org/10.1016/b978-0-12-378630-2.00624-1" @default.
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