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- W85815799 abstract "The authors investigated the hypothesis that altered intracellular pH may modulate lung surfactant secretion. They have used isolated perfused lung preparation to investigate release of (/sup 3/H)choline labeled phosphatidylcholine (PC) in the alveolar space of rat lungs ventilated with 5%, 2.5%, or 0% CO/sub 2/ in air. Adult rats were injected i.p. 40uCi of (/sup 3/H-methyl) choline and lungs removed after 45 min. Lungs were perfused for 15 or 60 min. with KRB plus 25 mM HEPES. At the end of perfusion lungs were lavaged five times with 7 ml of ice cold saline. Lavage fluid, was centrifuged, lyophilized, and both lung and lavage fluid extracted for lipids. Lipid choline label in lavage fluid, expressed as percent of that in lung lipids, from control lungs (5% CO/sub 2/) showed 0.6 +/- 0.1 % at 15 min and 1.1 +/- 0.3% (mean +/- SE, n=6) label at 60 min. When perfused with 50 ..mu..M 1-isoproterenol, the label after 60 min perfusion increased to 2.76 +/- 0.33 (n=3). Ventilation with air containing 2.5% CO/sub 2/ and 0% CO/sub 2/ showed 6.1 +/- 2.1 % (n=4) and 6.4 +/- 1.8% (n=4) label in lavage fluid. Addition of 25mM sodium acetate in the perfusionmore » medium and ventilation with 0% CO/sub 2/ in air lowered release of label to 4.2 +/- 1.4% (n=4). These results show that low pCO/sub 2/ increases surfactant PC secretion in lung and suggest that intracellular alkalosis triggers surfactant release.« less" @default.
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- W85815799 date "1986-03-05" @default.
- W85815799 modified "2023-09-23" @default.
- W85815799 title "Surfactant secretion is stimulated by decreased alveolar CO/sub 2/" @default.
- W85815799 hasPublicationYear "1986" @default.
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