FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W85833199> ?p ?o ?g. }

• W85833199 endingPage "1894" @default.
• W85833199 startingPage "1887" @default.
• W85833199 abstract "Abstract Bone marrow transplantation (BMT) is followed by a period of profound immune deficiency, during which new T lymphocytes are generated from either stem cells or immature thymic progenitors. Interleukin-7 (IL-7) induces proliferation and differentiation of immature thymocytes. We examined whether the in vivo administration of IL-7 to mice receiving BMT would alter thymic reconstitution. Lethally irradiated C57BL/6 mice received syngeneic BMT, followed by either IL-7 or placebo from days 5 to 18 post-BMT. At day 28, BMT recipients that had not received IL-7 had profound thymic hypoplasia (< 5% of normal), with relative increases in the numbers of immature thymocytes, decreased numbers of mature peripheral (splenic) T lymphocytes, and severely impaired T- and B-cell function. In contrast, transplanted mice treated with IL-7 had normalization of thymic cellularity, with normal proportions of thymic subsets and T-cell receptor beta variable gene (TCRV beta) usage, normal numbers of peripheral CD4+ T lymphocytes, and improved antigen- specific T- and B-cell function. In the BMT-IL-7 mice, there was an eightfold increase in the number of immature CD3-CD4-CD8- thymocytes in G2-M of the cell cycle, indicating that restoration of thymic cellularity was due to enhanced proliferation of immature thymic progenitors. Similar effects following IL-7 administration were also observed when donor bone marrow was depleted of mature T lymphocytes, indicating that IL-7 administration affected immature hematopoietic progenitors. IL-7 promotes thymic reconstitution after BMT, and may be useful in preventing post-BMT immune deficiency." @default.
• W85833199 created "2016-06-24" @default.
• W85833199 creator A5011140205 @default.
• W85833199 creator A5015474411 @default.
• W85833199 creator A5042319569 @default.
• W85833199 creator A5046180673 @default.
• W85833199 creator A5049814181 @default.
• W85833199 date "1996-09-01" @default.
• W85833199 modified "2023-10-16" @default.
• W85833199 title "Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7" @default.
• W85833199 cites W1493657254 @default.
• W85833199 cites W1499837259 @default.
• W85833199 cites W1569343698 @default.
• W85833199 cites W1661062711 @default.
• W85833199 cites W168192535 @default.
• W85833199 cites W1971496886 @default.
• W85833199 cites W1971741645 @default.
• W85833199 cites W2009607549 @default.
• W85833199 cites W2009664834 @default.
• W85833199 cites W2044762859 @default.
• W85833199 cites W2054938881 @default.
• W85833199 cites W2086428834 @default.
• W85833199 cites W2096632716 @default.
• W85833199 cites W2162743131 @default.
• W85833199 cites W2253902778 @default.
• W85833199 cites W2345179342 @default.
• W85833199 cites W2407137422 @default.
• W85833199 cites W2412863046 @default.
• W85833199 cites W2417754142 @default.
• W85833199 cites W242181897 @default.
• W85833199 cites W2462895704 @default.
• W85833199 cites W66152330 @default.
• W85833199 doi "https://doi.org/10.1182/blood.v88.5.1887.1887" @default.
• W85833199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8781449" @default.
• W85833199 hasPublicationYear "1996" @default.
• W85833199 type Work @default.
• W85833199 sameAs 85833199 @default.
• W85833199 citedByCount "217" @default.
• W85833199 countsByYear W858331992012 @default.
• W85833199 countsByYear W858331992013 @default.
• W85833199 countsByYear W858331992014 @default.
• W85833199 countsByYear W858331992015 @default.
• W85833199 countsByYear W858331992016 @default.
• W85833199 countsByYear W858331992017 @default.
• W85833199 countsByYear W858331992018 @default.
• W85833199 countsByYear W858331992019 @default.
• W85833199 countsByYear W858331992020 @default.
• W85833199 countsByYear W858331992021 @default.
• W85833199 countsByYear W858331992022 @default.
• W85833199 crossrefType "journal-article" @default.
• W85833199 hasAuthorship W85833199A5011140205 @default.
• W85833199 hasAuthorship W85833199A5015474411 @default.
• W85833199 hasAuthorship W85833199A5042319569 @default.
• W85833199 hasAuthorship W85833199A5046180673 @default.
• W85833199 hasAuthorship W85833199A5049814181 @default.
• W85833199 hasBestOaLocation W858331991 @default.
• W85833199 hasConcept C109159458 @default.
• W85833199 hasConcept C126322002 @default.
• W85833199 hasConcept C134018914 @default.
• W85833199 hasConcept C167672396 @default.
• W85833199 hasConcept C201750760 @default.
• W85833199 hasConcept C203014093 @default.
• W85833199 hasConcept C2776090121 @default.
• W85833199 hasConcept C2777371288 @default.
• W85833199 hasConcept C2778954852 @default.
• W85833199 hasConcept C2780007613 @default.
• W85833199 hasConcept C28328180 @default.
• W85833199 hasConcept C71924100 @default.
• W85833199 hasConcept C79904392 @default.
• W85833199 hasConcept C86803240 @default.
• W85833199 hasConcept C8891405 @default.
• W85833199 hasConcept C95444343 @default.
• W85833199 hasConceptScore W85833199C109159458 @default.
• W85833199 hasConceptScore W85833199C126322002 @default.
• W85833199 hasConceptScore W85833199C134018914 @default.
• W85833199 hasConceptScore W85833199C167672396 @default.
• W85833199 hasConceptScore W85833199C201750760 @default.
• W85833199 hasConceptScore W85833199C203014093 @default.
• W85833199 hasConceptScore W85833199C2776090121 @default.
• W85833199 hasConceptScore W85833199C2777371288 @default.
• W85833199 hasConceptScore W85833199C2778954852 @default.
• W85833199 hasConceptScore W85833199C2780007613 @default.
• W85833199 hasConceptScore W85833199C28328180 @default.
• W85833199 hasConceptScore W85833199C71924100 @default.
• W85833199 hasConceptScore W85833199C79904392 @default.
• W85833199 hasConceptScore W85833199C86803240 @default.
• W85833199 hasConceptScore W85833199C8891405 @default.
• W85833199 hasConceptScore W85833199C95444343 @default.
• W85833199 hasIssue "5" @default.
• W85833199 hasLocation W858331991 @default.
• W85833199 hasOpenAccess W85833199 @default.
• W85833199 hasPrimaryLocation W858331991 @default.
• W85833199 hasRelatedWork W1977841877 @default.
• W85833199 hasRelatedWork W2054197229 @default.
• W85833199 hasRelatedWork W2147235077 @default.
• W85833199 hasRelatedWork W2153619276 @default.
• W85833199 hasRelatedWork W2163954477 @default.
• W85833199 hasRelatedWork W2188518547 @default.

• next