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• W8583422 abstract "The biotransformation of digitoxin and some of its derivatives extracted from Digitalis lanata by Streptomyces isolated species was investigated. Cultures of a Streptomyces strain designated EUSA2003B, isolated from an Egyptian soil sample, efficiently induced selective 12-hydroxylation of the steroid aglycone of digitoxin (DT) and its -acetyl and -methyl derivatives. The transformation reaction was performed within a 5-day fermentation process, products were isolated and their aglycone moiety was obtained by acid hydrolysis and their structures were elucidated by 13 C and 1 H NMR. The biotransformation resulted mainlydigoxin(DG, ∼87%),meanwhile,digoxigenone(DGON, ∼7.0%)wasalsoaffordedasasideproduct. The present study revealed that: 1-Streptomyces isolate EUSA2003B harbors its specific 12-hydroxlase and has the capability to transform DT and it’s -acetyl and -methyl derivatives into their corresponding digoxins at reasonable yields. 2-The minor structural differences in the trisaccharide side chain seemed ineffective on the transformational capability of this organism. 3-The Streptomyces might also possess a specific glycosidase that splits the saccharidic side chain beside another dehydrogenase that oxidizes C3 at the steroid nucleus into its ketone form (DGON)." @default.
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• W8583422 date "2011-06-01" @default.
• W8583422 modified "2023-09-23" @default.
• W8583422 title "Biotransformation of extracted digitoxin from Digitalis lanata by Streptomyces." @default.
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• W8583422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21699088" @default.
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