Matches in SemOpenAlex for { <https://semopenalex.org/work/W8585246> ?p ?o ?g. }
- W8585246 endingPage "150" @default.
- W8585246 startingPage "105" @default.
- W8585246 abstract "This chapter discusses the stimulation of adenylyl cyclases by hormones and regulation by nucleotides. Most of the actions of peptide and protein hormones, and those of the biogenic amines are the result of a primary interaction with a membrane-bound receptor that initiates a train of events leading to activation of a nearby adenylyl cyclase molecule and to formation of the second messenger, cAMP. The enzyme system is complex and the mode by which the occupied hormone receptor stimulates its activity is still unknown. None of the components of a hormone-sensitive adenylyl cyclase system, be it receptor, catalytic unit, or coupling factor, has yet been purified to homogeneity, and it is not clear whether all of them have even been identified. As, with one exception, solubilization of the systems has resulted in loss of hormonal responsiveness, their exploration has extensively utilized indirect approaches. Indirect exploration has had to take several factors into account: (1) effects seen may be because of alteration of the phospholipid matrix surrounding adenylyl cyclase and not because of direct action on the enzyme; (2) the system may be polymeric, being composed of several receptor and catalytic units; and (3) kinetic modeling under both pre- and post-steady-state conditions may lend itself to several interpretations that are seldom mutually exclusive. In recent years, it has become increasingly clear that the hormonal activation of adenylyl cyclase systems is under regulation by nucleotides and nucleosides. The type of modulation effected by nucleotides varies with the system studied. Both positive and negative effects on hormonal stimulation have been observed with either nucleoside triphosphates or nucleoside diphosphates." @default.
- W8585246 created "2016-06-24" @default.
- W8585246 creator A5003363567 @default.
- W8585246 creator A5053083913 @default.
- W8585246 creator A5068945189 @default.
- W8585246 creator A5083594474 @default.
- W8585246 date "1977-01-01" @default.
- W8585246 modified "2023-09-25" @default.
- W8585246 title "Adenylyl cyclases: stimulation by hormones and regulation by nucleotides**Supported in part by grants from the US Public Health Service (HD-06513, HD-06273, HD-09581 and HD-07495) and from the Clayton Foundation." @default.
- W8585246 cites W1480699529 @default.
- W8585246 cites W1482760007 @default.
- W8585246 cites W1483243352 @default.
- W8585246 cites W1484140691 @default.
- W8585246 cites W1486608945 @default.
- W8585246 cites W1487187369 @default.
- W8585246 cites W1488609485 @default.
- W8585246 cites W1490501514 @default.
- W8585246 cites W1490796893 @default.
- W8585246 cites W1495836825 @default.
- W8585246 cites W1500611446 @default.
- W8585246 cites W1501394106 @default.
- W8585246 cites W1501471226 @default.
- W8585246 cites W1501966066 @default.
- W8585246 cites W1505822003 @default.
- W8585246 cites W1509728658 @default.
- W8585246 cites W1510838637 @default.
- W8585246 cites W1511183935 @default.
- W8585246 cites W1519118419 @default.
- W8585246 cites W1519711690 @default.
- W8585246 cites W1520821251 @default.
- W8585246 cites W1522538207 @default.
- W8585246 cites W1522861873 @default.
- W8585246 cites W1528765423 @default.
- W8585246 cites W1528995211 @default.
- W8585246 cites W1529705405 @default.
- W8585246 cites W1530817906 @default.
- W8585246 cites W1531386924 @default.
- W8585246 cites W1531829990 @default.
- W8585246 cites W1533569247 @default.
- W8585246 cites W1533618603 @default.
- W8585246 cites W1534116154 @default.
- W8585246 cites W1538010644 @default.
- W8585246 cites W1539671198 @default.
- W8585246 cites W1545031061 @default.
- W8585246 cites W1546236203 @default.
- W8585246 cites W1548524206 @default.
- W8585246 cites W1549058772 @default.
- W8585246 cites W1551160005 @default.
- W8585246 cites W1551812698 @default.
- W8585246 cites W1553844574 @default.
- W8585246 cites W1555760915 @default.
- W8585246 cites W1555784209 @default.
- W8585246 cites W1558128541 @default.
- W8585246 cites W1565859051 @default.
- W8585246 cites W1567589799 @default.
- W8585246 cites W1571164069 @default.
- W8585246 cites W1573331976 @default.
- W8585246 cites W1577436652 @default.
- W8585246 cites W1578024134 @default.
- W8585246 cites W1589654194 @default.
- W8585246 cites W1590115463 @default.
- W8585246 cites W1591730122 @default.
- W8585246 cites W1591872616 @default.
- W8585246 cites W1592059338 @default.
- W8585246 cites W1605968678 @default.
- W8585246 cites W1608381236 @default.
- W8585246 cites W1609280109 @default.
- W8585246 cites W1609365613 @default.
- W8585246 cites W1615878305 @default.
- W8585246 cites W1654759002 @default.
- W8585246 cites W1657719861 @default.
- W8585246 cites W1672787784 @default.
- W8585246 cites W1677760409 @default.
- W8585246 cites W1863678882 @default.
- W8585246 cites W18764957 @default.
- W8585246 cites W1897633092 @default.
- W8585246 cites W1915200954 @default.
- W8585246 cites W1964004000 @default.
- W8585246 cites W1964806454 @default.
- W8585246 cites W1977005638 @default.
- W8585246 cites W1977736756 @default.
- W8585246 cites W1978059414 @default.
- W8585246 cites W1979335028 @default.
- W8585246 cites W1981216250 @default.
- W8585246 cites W1981949727 @default.
- W8585246 cites W1982245388 @default.
- W8585246 cites W1984030198 @default.
- W8585246 cites W1984640467 @default.
- W8585246 cites W1984746179 @default.
- W8585246 cites W1985815865 @default.
- W8585246 cites W1991218053 @default.
- W8585246 cites W2008053750 @default.
- W8585246 cites W2009904107 @default.
- W8585246 cites W2012437933 @default.
- W8585246 cites W2019371103 @default.
- W8585246 cites W2020349910 @default.
- W8585246 cites W2023634139 @default.
- W8585246 cites W2030307222 @default.