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- W858703549 abstract "This chapter discusses warfarin metabolism and presents the results of a probe of purified rat liver cytochromes P-450. In a study described in the chapter, racemic warfarin was resolved and the warfarin metabolites were synthesized. The cytochromes were purified from livers of male Sprague Dawley rats (100–125 g), which were untreated (UT) or induced with PB or MC. The procedures for the separation and purification of the cytochromes have been described and the preparations used in that study were from untreated rats (UT-A, UT-C), PB-induced rats (PB-B, PB-C), and MC-induced rats (MC-A, MC-B). NADPH-cytochrome P-450 reductase was prepared from rat liver microsomes. Cytochromes, P-450 PB-B and MC-B, were used to raise antibodies in female New Zealand rabbits. The results revealed that UT-A and UT-C yielded different patterns of metabolites. UT-A showed no regioselectivity, while UT-C was clearly regioselective for 7-hydroxywarfarin. UT-A demonstrated no stereoselectivity, while UT-C was stereoselective for S-warfarin. UT-A was threefold more active than UT-C in overall rates." @default.
- W858703549 created "2016-06-24" @default.
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- W858703549 date "1980-01-01" @default.
- W858703549 modified "2023-09-25" @default.
- W858703549 title "WARFARIN METABOLISM - A PROBE OF PURIFIED RAT LIVER CYTOCHROMES P-450" @default.
- W858703549 cites W2333831301 @default.
- W858703549 doi "https://doi.org/10.1016/b978-0-12-187701-9.50027-9" @default.
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