Matches in SemOpenAlex for { <https://semopenalex.org/work/W858798890> ?p ?o ?g. }
- W858798890 endingPage "87" @default.
- W858798890 startingPage "77" @default.
- W858798890 abstract "Prepulse inhibition is a measure of sensorimotor gating, which reflects the ability to filter or 'gate' irrelevant information. Prepulse inhibition is dramatically altered in basal ganglia disorders associated with dysfunction in the midbrain dopaminergic system, and corresponding cognitive information processing deficits such as slowed processing speed. Parkinson's disease is characterised by the degeneration of the midbrain dopaminergic system and is associated with cognitive dysfunction, including slowed information processing. Although sensorimotor processes in Parkinson's disease have been extensively studied in relation to motor function, less is known about the potential role of sensorimotor processes in cognitive function.We investigated the relationship between prepulse inhibition, cognition and nigrostriatal dysfunction, as measured with 123I-FP-CIT-SPECT scanning, in patients with Parkinson's disease.38 Parkinson patients were assessed with prepulse inhibition, neuropsychological tests, and neurological investigation. A subset of these patients underwent 123I-FP-CIT-SPECT scanning.Patients with a higher level of prepulse inhibition performed better on cognitive measures tapping attention and processing speed than patients with a lower level of prepulse inhibition. Furthermore, there were significant correlations between prepulse inhibition and 123I-FP-CIT uptake in the striatum.Our results suggest that the level of prepulse inhibition is related to the efficiency of information processing in Parkinson's disease, and to the density of dopamine transporters in the striatum." @default.
- W858798890 created "2016-06-24" @default.
- W858798890 creator A5010574775 @default.
- W858798890 creator A5012377993 @default.
- W858798890 creator A5029314874 @default.
- W858798890 creator A5029444100 @default.
- W858798890 creator A5047864013 @default.
- W858798890 creator A5049561335 @default.
- W858798890 date "2014-01-01" @default.
- W858798890 modified "2023-09-27" @default.
- W858798890 title "Prepulse Inhibition is Associated with Attention, Processing Speed, and 123I-FP-CIT SPECT in Parkinson's Disease" @default.
- W858798890 cites W1253281790 @default.
- W858798890 cites W1484914051 @default.
- W858798890 cites W1490631519 @default.
- W858798890 cites W1496608909 @default.
- W858798890 cites W1501725216 @default.
- W858798890 cites W1896935017 @default.
- W858798890 cites W1971309447 @default.
- W858798890 cites W1972995503 @default.
- W858798890 cites W1975222329 @default.
- W858798890 cites W1980020952 @default.
- W858798890 cites W1980967004 @default.
- W858798890 cites W1983273341 @default.
- W858798890 cites W1989288468 @default.
- W858798890 cites W1989428075 @default.
- W858798890 cites W1991876306 @default.
- W858798890 cites W1992661874 @default.
- W858798890 cites W1993633317 @default.
- W858798890 cites W1994982044 @default.
- W858798890 cites W2002948818 @default.
- W858798890 cites W2009033786 @default.
- W858798890 cites W2011861646 @default.
- W858798890 cites W2014550164 @default.
- W858798890 cites W2016927854 @default.
- W858798890 cites W2018993369 @default.
- W858798890 cites W2019904197 @default.
- W858798890 cites W2027579066 @default.
- W858798890 cites W2037828207 @default.
- W858798890 cites W2052508372 @default.
- W858798890 cites W2054619289 @default.
- W858798890 cites W2055718946 @default.
- W858798890 cites W2056941807 @default.
- W858798890 cites W2057198064 @default.
- W858798890 cites W2060884332 @default.
- W858798890 cites W2064858427 @default.
- W858798890 cites W2065206359 @default.
- W858798890 cites W2065916789 @default.
- W858798890 cites W2066433054 @default.
- W858798890 cites W2067603001 @default.
- W858798890 cites W2068847058 @default.
- W858798890 cites W2071719190 @default.
- W858798890 cites W2079730191 @default.
- W858798890 cites W2085916486 @default.
- W858798890 cites W2090979638 @default.
- W858798890 cites W2094134651 @default.
- W858798890 cites W2094450187 @default.
- W858798890 cites W2096574063 @default.
- W858798890 cites W2096799953 @default.
- W858798890 cites W2101322261 @default.
- W858798890 cites W2108888040 @default.
- W858798890 cites W2116704462 @default.
- W858798890 cites W2119400000 @default.
- W858798890 cites W2120653271 @default.
- W858798890 cites W2121100767 @default.
- W858798890 cites W2127118940 @default.
- W858798890 cites W2129207020 @default.
- W858798890 cites W2129665374 @default.
- W858798890 cites W2133067994 @default.
- W858798890 cites W2144944518 @default.
- W858798890 cites W2145602532 @default.
- W858798890 cites W2149663041 @default.
- W858798890 cites W2155236630 @default.
- W858798890 cites W2159659046 @default.
- W858798890 cites W2163320407 @default.
- W858798890 cites W2164561646 @default.
- W858798890 cites W2167212163 @default.
- W858798890 cites W23205908 @default.
- W858798890 cites W91587258 @default.
- W858798890 cites W2134283778 @default.
- W858798890 doi "https://doi.org/10.3233/jpd-130307" @default.
- W858798890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24366928" @default.
- W858798890 hasPublicationYear "2014" @default.
- W858798890 type Work @default.
- W858798890 sameAs 858798890 @default.
- W858798890 citedByCount "14" @default.
- W858798890 countsByYear W8587988902014 @default.
- W858798890 countsByYear W8587988902015 @default.
- W858798890 countsByYear W8587988902016 @default.
- W858798890 countsByYear W8587988902017 @default.
- W858798890 countsByYear W8587988902019 @default.
- W858798890 countsByYear W8587988902021 @default.
- W858798890 countsByYear W8587988902022 @default.
- W858798890 crossrefType "journal-article" @default.
- W858798890 hasAuthorship W858798890A5010574775 @default.
- W858798890 hasAuthorship W858798890A5012377993 @default.
- W858798890 hasAuthorship W858798890A5029314874 @default.
- W858798890 hasAuthorship W858798890A5029444100 @default.
- W858798890 hasAuthorship W858798890A5047864013 @default.