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• W85880014 abstract "The clinical diagnosis of probable Alzheimer’s disease (AD) is based on a group of signs, symptoms, and test results (1–7). No single diagnostic test has been identified, and a definitive diagnosis therefore requires biopsy or autopsy confirmation. The formal role of imaging in establishing a clinical diagnosis of probable AD is an exclusionary one—that is, to exclude possible causes of dementia other than AD which may be identified through imaging. However, investigators have sought to identify positive diagnostic imaging criteria, which may aid in the clinical diagnosis of AD. A number of different imaging techniques or modalities have been employed to this end. Functional imaging modalities may reveal a characteristic regional bilateral temporal/parietal lobe or posterior cingulate deficit in patients with AD. Functional deficits identified with positron emission tomography (PET) scanning include regional deficits in glucose and oxygen metabolism as well as blood flow (8–10).Single photon emission computed tomography (SPELT) may reveal similar regional deficits in blood flow (11–13).More recently, deficits in regional cerebral blood volume have been identified with magnetic resonance (MR) perfusion techniques (14).Biochemical alterations have been identified with MR spectroscopy. The two metabolites most commonly targeted for in vivo MR spectroscopy studies are hydrogen and phosphorus. To date, the results" @default.
• W85880014 created "2016-06-24" @default.
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• W85880014 date "2000-01-01" @default.
• W85880014 modified "2023-09-23" @default.
• W85880014 title "Structural Imaging Approaches to Alzheimer’s Disease" @default.
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• W85880014 doi "https://doi.org/10.1007/978-1-59259-005-6_6" @default.
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