Matches in SemOpenAlex for { <https://semopenalex.org/work/W85883242> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W85883242 endingPage "225" @default.
- W85883242 startingPage "216" @default.
- W85883242 abstract "Abstract A new technique is introduced for determining the number of bone marrow cells per cubic millimeter marrow, providing an accurate and objective means for quantitating therapy-induced cytoreduction. The method requires a correction for admixed peripheral blood in bone marrow aspirates to measure the fraction of remaining pure marrow. While cell kinetic differences between blood, aspirates, and biopsies identify the proportion of contaminating blood cells, the ratio of red cell hematocrits in blood and aspirate gives the volume of trapped blood. By combining both procedures, bone marrow cell counts per unit volume pure marrow result (BMC/cu mm BM), which were found highly reproducible. Blast cell counts (BMBC/cu mm BM) were obtained by additional morphological differentiation. BMC and BMBC/cu mm BM were monitored in 16 patients with acute nonlymphoblastic leukemia treated with daunorubicin, cytosine arabinoside, and 6-thioguanine in combination and in 4 patients with end-stage acute leukemias and non-Hodgkin's lymphomas during high-dose thymidine therapy. Total and daily therapy- induced cytoreduction rates were significantly greater (P less than 0.01) in responders than nonresponders to either regimen. Changes in BMC/cu mm BM were also found representative for changes in BMBC/cu mm BM, since the majority of bone marrow cells were blasts. In acute leukemia. BMC/cu mm BM thus provides accurate and objective measurements of treatment efficacy in vivo and after short periods of drug exposure. Differences in cytoreduction rates within the group of responders also suggest possible prognostic implications." @default.
- W85883242 created "2016-06-24" @default.
- W85883242 creator A5004888325 @default.
- W85883242 creator A5025381409 @default.
- W85883242 creator A5033935778 @default.
- W85883242 creator A5051515853 @default.
- W85883242 creator A5071091625 @default.
- W85883242 date "1982-02-01" @default.
- W85883242 modified "2023-09-29" @default.
- W85883242 title "Bone marrow cell count per cubic millimeter bone marrow: a new parameter for quantitating therapy-induced cytoreduction in acute leukemia" @default.
- W85883242 cites W1802606188 @default.
- W85883242 cites W1979539936 @default.
- W85883242 cites W1981247439 @default.
- W85883242 cites W1990656269 @default.
- W85883242 cites W2016162177 @default.
- W85883242 cites W2021893910 @default.
- W85883242 cites W2033948357 @default.
- W85883242 cites W2036545615 @default.
- W85883242 cites W2037526370 @default.
- W85883242 cites W2040402999 @default.
- W85883242 cites W2042590058 @default.
- W85883242 cites W2049946525 @default.
- W85883242 cites W2061210880 @default.
- W85883242 cites W2128431707 @default.
- W85883242 cites W2132167316 @default.
- W85883242 cites W2219090764 @default.
- W85883242 cites W2291033815 @default.
- W85883242 cites W2333900045 @default.
- W85883242 cites W2396068685 @default.
- W85883242 cites W2409002642 @default.
- W85883242 cites W2415951633 @default.
- W85883242 cites W2437359329 @default.
- W85883242 cites W259228920 @default.
- W85883242 cites W2889483060 @default.
- W85883242 cites W31903692 @default.
- W85883242 doi "https://doi.org/10.1182/blood.v59.2.216.216" @default.
- W85883242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7055637" @default.
- W85883242 hasPublicationYear "1982" @default.
- W85883242 type Work @default.
- W85883242 sameAs 85883242 @default.
- W85883242 citedByCount "34" @default.
- W85883242 countsByYear W858832422012 @default.
- W85883242 countsByYear W858832422013 @default.
- W85883242 countsByYear W858832422015 @default.
- W85883242 countsByYear W858832422017 @default.
- W85883242 countsByYear W858832422021 @default.
- W85883242 countsByYear W858832422022 @default.
- W85883242 crossrefType "journal-article" @default.
- W85883242 hasAuthorship W85883242A5004888325 @default.
- W85883242 hasAuthorship W85883242A5025381409 @default.
- W85883242 hasAuthorship W85883242A5033935778 @default.
- W85883242 hasAuthorship W85883242A5051515853 @default.
- W85883242 hasAuthorship W85883242A5071091625 @default.
- W85883242 hasBestOaLocation W858832421 @default.
- W85883242 hasConcept C126322002 @default.
- W85883242 hasConcept C142724271 @default.
- W85883242 hasConcept C2776694085 @default.
- W85883242 hasConcept C2776863199 @default.
- W85883242 hasConcept C2778461978 @default.
- W85883242 hasConcept C2779979121 @default.
- W85883242 hasConcept C2780007613 @default.
- W85883242 hasConcept C2781021840 @default.
- W85883242 hasConcept C2781413609 @default.
- W85883242 hasConcept C2989005 @default.
- W85883242 hasConcept C71924100 @default.
- W85883242 hasConcept C90924648 @default.
- W85883242 hasConceptScore W85883242C126322002 @default.
- W85883242 hasConceptScore W85883242C142724271 @default.
- W85883242 hasConceptScore W85883242C2776694085 @default.
- W85883242 hasConceptScore W85883242C2776863199 @default.
- W85883242 hasConceptScore W85883242C2778461978 @default.
- W85883242 hasConceptScore W85883242C2779979121 @default.
- W85883242 hasConceptScore W85883242C2780007613 @default.
- W85883242 hasConceptScore W85883242C2781021840 @default.
- W85883242 hasConceptScore W85883242C2781413609 @default.
- W85883242 hasConceptScore W85883242C2989005 @default.
- W85883242 hasConceptScore W85883242C71924100 @default.
- W85883242 hasConceptScore W85883242C90924648 @default.
- W85883242 hasIssue "2" @default.
- W85883242 hasLocation W858832421 @default.
- W85883242 hasOpenAccess W85883242 @default.
- W85883242 hasPrimaryLocation W858832421 @default.
- W85883242 hasRelatedWork W2007979338 @default.
- W85883242 hasRelatedWork W2035670650 @default.
- W85883242 hasRelatedWork W2093076886 @default.
- W85883242 hasRelatedWork W2266287318 @default.
- W85883242 hasRelatedWork W2367707652 @default.
- W85883242 hasRelatedWork W2377863656 @default.
- W85883242 hasRelatedWork W2413329463 @default.
- W85883242 hasRelatedWork W3032383209 @default.
- W85883242 hasRelatedWork W4232440048 @default.
- W85883242 hasRelatedWork W85883242 @default.
- W85883242 hasVolume "59" @default.
- W85883242 isParatext "false" @default.
- W85883242 isRetracted "false" @default.
- W85883242 magId "85883242" @default.
- W85883242 workType "article" @default.