FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W85961998> ?p ?o ?g. }

• W85961998 endingPage "71" @default.
• W85961998 startingPage "62" @default.
• W85961998 abstract "In lieu of an abstract, below is the first paragraph of the paper. Harmful Algal Blooms (HABs) along the west coast of Florida are the result of a large proliferation of the dinoflagellate Karenia brevis. The harmful nature of these algal blooms is the result of potent neurotoxins, specifically referred to as brevetoxins, which are released from K. brevis. PbTx-2 is one of the most abundant brevetoxins during HABs of K brevis and results in extreme mortality of marine wildlife and health implications for humans such as Neurotoxic Shellfish Poisoning (NSP) and immunosuppression. The cellular response to PbTx-2 is not as well known, which was the focus of this research. Oxidative stress, in the form of depleted glutathione and elevated levels of hydrogen peroxide, peroxidase, and/or heme oxygenase-1 (HO-1), is a common defensive response of human cells to a toxin. It was hypothesized that human cells would produce an elevated level of HO-1 in the presence of PbTx2 in comparison to cells without PbTx-2. The purpose of this research was to quantify the amount of HO-1 produced by a human monocytic cell line (U-937) when treated with PbTx-2 and use this as an indicator of the level of oxidative stress. Results supported that human cells did undergo oxidative stress in the presence of PbTx-2 and produced an elevated level of HO-1. This article is available in The Review: A Journal of Undergraduate Student Research: http://fisherpub.sjfc.edu/ur/vol10/iss1/11 Heme oxygenase-1 produced by a human monocytic cell line (U-937) after exposure to brevetoxin (PbTx-2) Carolyn Fisher, Catherine Walsh, and Stephanie L. Leggett Harmful Algal Blooms (HABs) along the west coast of Florida are the result of a large proliferation of the dinoflagellate Karenia brevis. The harmful nature of these algal blooms is the result of potent neurotoxins, specifically referred to as brevetoxins, which are released from K. brevis. PbTx-2 is one of the most abundant brevetoxins during HABs of K brevis and results in extreme mortality of marine wildlife and health implications for humans such as Neurotoxic Shellfish Poisoning (NSP) and immunosuppression. The cellular response to PbTx-2 is not as well known, which was the focus of this research. Oxidative stress, in the form of depleted glutathione and elevated levels of hydrogen peroxide, peroxidase, and/or heme oxygenase-1 (HO-1), is a common defensive response of human cells to a toxin. It was hypothesized that human cells would produce an elevated level of HO-1 in the presence of PbTx2 in comparison to cells without PbTx-2. The purpose of this research was to quantify the amount of HO-1 produced by a human monocytic cell line (U-937) when treated with PbTx-2 and use this as an indicator of the level of oxidative stress. Results supported that human cells did undergo oxidative stress in the presence of PbTx-2 and produced an elevated level of HO-" @default.
• W85961998 created "2016-06-24" @default.
• W85961998 creator A5014366832 @default.
• W85961998 creator A5020912406 @default.
• W85961998 creator A5025545206 @default.
• W85961998 date "2009-01-01" @default.
• W85961998 modified "2023-09-23" @default.
• W85961998 title "Heme Oxygnase-1 Produced by a Human Monocytic Cell Line (U-937) After Exposure to Brevetoxin (PbTx-2)" @default.
• W85961998 hasPublicationYear "2009" @default.
• W85961998 type Work @default.
• W85961998 sameAs 85961998 @default.
• W85961998 citedByCount "0" @default.
• W85961998 crossrefType "journal-article" @default.
• W85961998 hasAuthorship W85961998A5014366832 @default.
• W85961998 hasAuthorship W85961998A5020912406 @default.
• W85961998 hasAuthorship W85961998A5025545206 @default.
• W85961998 hasConcept C120305227 @default.
• W85961998 hasConcept C142796444 @default.
• W85961998 hasConcept C181199279 @default.
• W85961998 hasConcept C18903297 @default.
• W85961998 hasConcept C2776151105 @default.
• W85961998 hasConcept C2776217839 @default.
• W85961998 hasConcept C2776506862 @default.
• W85961998 hasConcept C2777367657 @default.
• W85961998 hasConcept C2779219270 @default.
• W85961998 hasConcept C2780204098 @default.
• W85961998 hasConcept C2780892065 @default.
• W85961998 hasConcept C2910844273 @default.
• W85961998 hasConcept C5465852 @default.
• W85961998 hasConcept C55493867 @default.
• W85961998 hasConcept C86803240 @default.
• W85961998 hasConceptScore W85961998C120305227 @default.
• W85961998 hasConceptScore W85961998C142796444 @default.
• W85961998 hasConceptScore W85961998C181199279 @default.
• W85961998 hasConceptScore W85961998C18903297 @default.
• W85961998 hasConceptScore W85961998C2776151105 @default.
• W85961998 hasConceptScore W85961998C2776217839 @default.
• W85961998 hasConceptScore W85961998C2776506862 @default.
• W85961998 hasConceptScore W85961998C2777367657 @default.
• W85961998 hasConceptScore W85961998C2779219270 @default.
• W85961998 hasConceptScore W85961998C2780204098 @default.
• W85961998 hasConceptScore W85961998C2780892065 @default.
• W85961998 hasConceptScore W85961998C2910844273 @default.
• W85961998 hasConceptScore W85961998C5465852 @default.
• W85961998 hasConceptScore W85961998C55493867 @default.
• W85961998 hasConceptScore W85961998C86803240 @default.
• W85961998 hasIssue "1" @default.
• W85961998 hasLocation W859619981 @default.
• W85961998 hasOpenAccess W85961998 @default.
• W85961998 hasPrimaryLocation W859619981 @default.
• W85961998 hasRelatedWork W1965212091 @default.
• W85961998 hasRelatedWork W1976009907 @default.
• W85961998 hasRelatedWork W2033052941 @default.
• W85961998 hasRelatedWork W2034814892 @default.
• W85961998 hasRelatedWork W2038111602 @default.
• W85961998 hasRelatedWork W2049627386 @default.
• W85961998 hasRelatedWork W2064142547 @default.
• W85961998 hasRelatedWork W2107553604 @default.
• W85961998 hasRelatedWork W2127252952 @default.
• W85961998 hasRelatedWork W2135506874 @default.
• W85961998 hasRelatedWork W2143720697 @default.
• W85961998 hasRelatedWork W2329515998 @default.
• W85961998 hasRelatedWork W2404895157 @default.
• W85961998 hasRelatedWork W2595656130 @default.
• W85961998 hasRelatedWork W2781806983 @default.
• W85961998 hasRelatedWork W334601663 @default.
• W85961998 hasRelatedWork W2139083630 @default.
• W85961998 hasRelatedWork W2182069465 @default.
• W85961998 hasRelatedWork W2187448903 @default.
• W85961998 hasRelatedWork W2788941362 @default.
• W85961998 hasVolume "10" @default.
• W85961998 isParatext "false" @default.
• W85961998 isRetracted "false" @default.
• W85961998 magId "85961998" @default.
• W85961998 workType "article" @default.