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- W860419107 abstract "This chapter discusses the DAF-1 receptor PK, which is encoded by the daf-1 gene, mutations in which cause the nematodes to develop into dauer larvae at a restrictive temperature even when food is abundant. The DAF-1 receptor functions to promote growth (non-dauer development) in abundant food. The position of three mutations in the daf-1 gene (two transposon insertions, m402 and m412, and one EMS-induced point mutation, m213) have been identified, and all three are in the coding region for the kinase domain. No ligand for the DAF-1 protein has been demonstrated by direct binding. However, daf-7, another gene whose function is required to prevent dauer larva formation, encodes a growth factor belonging to the TGFβ superfamily that is potentially the ligand. The daf-1 gene encodes a 2.5 kb transcript that is present at all stages of development. Transgenic nematodes carrying a fusion of the daf-1 promoter with a β-galactosidase reporter gene suggest that expression is localized to neurones in the head and tail." @default.
- W860419107 created "2016-06-24" @default.
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- W860419107 date "1995-01-01" @default.
- W860419107 modified "2023-10-14" @default.
- W860419107 title "DAF-1" @default.
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- W860419107 doi "https://doi.org/10.1016/b978-012324719-3/50113-8" @default.
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