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• W860764713 abstract "O controle de qualidade de farmacos desempenha um papel importante na saude publica ao garantir seguranca e eficacia de medicamentos. No sistema de saude publica, as farmacias magistrais tambem sao importantes. Elas fornecem medicamentos personalizados como produtos dermatologicos e doses especificas para criancas. Infelizmente, muitos casos de produtos magistrais fabricados fora do padrao minimo de qualidade tem sido relatados no Brasil. Neste trabalho, a qualidade das capsulas magistrais de fluconazol 150 mg foi avaliada e os resultados foram comparados com os valores recomendados pela Farmacopeia Brasileira. Os resultados sugerem que e possivel manipular produtos que satisfacam as especificacoes farmacopeicas, mas estes ainda mostram que ha farmacias magistrais onde o controle de qualidade e deficiente ou inexistente. O fluconazol e um farmaco importante no tratamento de infeccoes fungicas. Seu uso como forma farmaceutica manipulada sem elevados padroes de qualidade e fortemente relacionado com a falha terapeutica e intoxicacoes, assim como o surgimento de microorganismos resistentes. Portanto, a necessidade de melhoria dos processos nas farmacias magistrais se torna mais enfatico. Existem metodos validados que podem ser utilizados com sucesso para a analise de rotina de controle de qualidade e que podem ser implementados por qualquer farmacia de manipulacao.Palavras-chave: Fluconazol. Medicamentos magistrais. Controle de Qualidade. Saude publica.ABSTRACTThe quality control of drugs has an important role in public health, in ensuring the efficacy and safety of medicines. In the public health system, compounding pharmacies play a vital part. They provide medicines tailored to the individual patient, for example dermatological products and specific doses for children. Unfortunately, many cases of compounded products falling below the minimum quality standard have been reported in Brazil. In this study, the quality of compounded 150 mg fluconazole capsules was assessed and the results were compared with values stipulated in the Brazilian pharmacopoeia. The results suggest that, while it is certainly possible to prepare products meeting pharmacopoeial specifications, there are pharmacies where the quality control is deficient or nonexistent. Fluconazole is an important drug in combatting fungal infections. The use of fluconazole in dosage forms manufactured without high standards of quality control is strongly linked to treatment failure and cases of intoxication, as well as the emergence of resistant microorganisms. This highlights the urgent need for process improvement in compounding pharmacies. There are validated methods that can be successfully employed for routine quality control analysis that can be implemented by any compounding pharmacy.Keywords: Fluconazole. Compounded medicines. Quality control. Public health." @default.
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• W860764713 date "2014-01-01" @default.
• W860764713 modified "2023-09-26" @default.
• W860764713 title "Assessment of the quality evaluation of compounded fluconazole capsules marketed in the region of Araraquara (SP, Brazil)" @default.
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