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- W860975737 abstract "Drug addiction and reward learning both involve mechanisms in which reinforcing neuromodulators participate in changing synaptic strength. For example, dopamine receptor activation modulates corticostriatal plasticity through a mechanism involving the induction of the immediate early gene Homer 1a, the phosphorylation of metabotropic glutamate receptor 5 (mGluR5)′s Homer ligand, and the enhancement of an NMDA receptor-dependent current. Inspired by hypotheses that Homer 1a functions selectively in recently-active synapses, we propose that Homer 1a is recruited by a synaptic tag to functionally discriminate between synapses that predict reward and those that do not. The involvement of Homer 1a in this mechanism further suggests that decaminutes-old firing patterns can define which synapses encode new information. This article is part of a Special Issue entitled SI:Addiction circuits." @default.
- W860975737 created "2016-06-24" @default.
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- W860975737 date "2015-12-01" @default.
- W860975737 modified "2023-10-14" @default.
- W860975737 title "Homer 1a and mGluR5 phosphorylation in reward-sensitive metaplasticity: A hypothesis of neuronal selection and bidirectional synaptic plasticity" @default.
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- W860975737 doi "https://doi.org/10.1016/j.brainres.2015.06.037" @default.
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