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- W861176820 abstract "Objective To investigate the effect of Huganheji in the liver functions.These included the production TGF-β1,the growth of the HSC-T6 cells and the expression of the type Ⅰ and Ⅲ collagens. Methods BCG and lipopolysaccharide-induced liver damage rat model was used in this study.Rats with liver damage were then treated with Huganheji. The levels of serum ALT, AST and TGF-β1 were examined. Sera obtained from these rats were collected and tested in HSC-T6 cell cultures. Cell growth was evaluated by the MTT assay. Expression of the type Ⅰ and Ⅲ collagen was evaluated by RT-PCR and electrophoresis. Results The levels of ALT, AST and TGF-β1 were significantly increased(P0.01) in rats with liver damage. However, the levels of ALT, AST and TGF-β1 were decreased(P0.01) after Huganheji treatment. Serum from Huganheji-treated rats could also reduce (P0.01) the growth of HSC -T6 cells and suppressed the expression of type Ⅰ and Ⅲ collagen. Conclusion Huganheji can improve liver fibrosis through the improvement of the liver function, decreasing the level of serum TGF-β1 and inhibiting the growth of the star-shaped liver cells." @default.
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- W861176820 date "2009-01-01" @default.
- W861176820 modified "2023-09-27" @default.
- W861176820 title "Effects of Huganheji on the activation and expression of collagen in star-shaped liver cells." @default.
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