FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W86169078> ?p ?o ?g. }

• W86169078 endingPage "1120" @default.
• W86169078 startingPage "1112" @default.
• W86169078 abstract "Abstract Membrane skeletal and cytoskeletal remodeling occurs throughout erythroid maturation. Microtubules and microfilaments have been identified morphologically in the nucleated erythroblast but the functional capability of these cytoskeletal structures during reticulocyte maturation has not been studied. Reticulocytes are formed from orthochromatic normoblasts by the process of nuclear extrusion. Two recognizable stages of reticulocyte maturation follow. The least mature reticulocytes are motile and multilobular, while the more mature reticulocytes are cup-shaped and nonmotile. To study the respective roles of microtubules and microfilaments in nuclear extrusion and cell motility, experiments were performed with agents that perturb these structures. Following the injection into rats of colchicine, a microtubule-disrupting substance, the number of normoblasts arrested at the stage of nuclear extrusion increased linearly over four hours. Similar results were obtained when bone marrow cells were incubated in culture in the presence of colchicine. In contrast, cell motility was dramatically decreased by cytochalasin B, a microfilament-disrupting agent, but not by colchicine. These results imply that microtubules are essential for the nuclear extrusion process, while microfilaments are essential for cell motility. Simultaneous changes in membrane skeletal assembly were assessed by measuring membrane deformability and stability, two properties regulated by the skeletal proteins. In ektacytometric assays, membrane deformability and mechanical stability of immature reticulocytes were markedly decreased to approximately 10% of normal, while that of more mature reticulocytes were nearly normal. Since the skeletal protein organization regulates these membrane properties, our findings imply that substantial membrane skeletal remodeling occurs during reticulocyte maturation. Thus we have identified major remodeling of both skeletal and cytoskeletal components during reticulocyte maturation." @default.
• W86169078 created "2016-06-24" @default.
• W86169078 creator A5030615975 @default.
• W86169078 creator A5034746599 @default.
• W86169078 creator A5044277046 @default.
• W86169078 creator A5056482307 @default.
• W86169078 date "1989-08-15" @default.
• W86169078 modified "2023-10-14" @default.
• W86169078 title "Membrane assembly and remodeling during reticulocyte maturation" @default.
• W86169078 cites W116951826 @default.
• W86169078 cites W1854787066 @default.
• W86169078 cites W1971961144 @default.
• W86169078 cites W1975376384 @default.
• W86169078 cites W1979592575 @default.
• W86169078 cites W1985700551 @default.
• W86169078 cites W1988945931 @default.
• W86169078 cites W1992056692 @default.
• W86169078 cites W1992682995 @default.
• W86169078 cites W1993836591 @default.
• W86169078 cites W1994733396 @default.
• W86169078 cites W1999168303 @default.
• W86169078 cites W2011196330 @default.
• W86169078 cites W2013257106 @default.
• W86169078 cites W2021816748 @default.
• W86169078 cites W2022804480 @default.
• W86169078 cites W2031686611 @default.
• W86169078 cites W2036878472 @default.
• W86169078 cites W2037383733 @default.
• W86169078 cites W2048859044 @default.
• W86169078 cites W2051265558 @default.
• W86169078 cites W2064759308 @default.
• W86169078 cites W2068736618 @default.
• W86169078 cites W2072866248 @default.
• W86169078 cites W2075641729 @default.
• W86169078 cites W2079707727 @default.
• W86169078 cites W2094987811 @default.
• W86169078 cites W2105539899 @default.
• W86169078 cites W2124908368 @default.
• W86169078 cites W2132268688 @default.
• W86169078 cites W2145504663 @default.
• W86169078 cites W2150313140 @default.
• W86169078 cites W2171523368 @default.
• W86169078 cites W2397651639 @default.
• W86169078 cites W2406698868 @default.
• W86169078 cites W2412174089 @default.
• W86169078 cites W2441844068 @default.
• W86169078 cites W2468713118 @default.
• W86169078 cites W301183615 @default.
• W86169078 cites W639556208 @default.
• W86169078 doi "https://doi.org/10.1182/blood.v74.3.1112.1112" @default.
• W86169078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2752157" @default.
• W86169078 hasPublicationYear "1989" @default.
• W86169078 type Work @default.
• W86169078 sameAs 86169078 @default.
• W86169078 citedByCount "164" @default.
• W86169078 countsByYear W861690782012 @default.
• W86169078 countsByYear W861690782013 @default.
• W86169078 countsByYear W861690782014 @default.
• W86169078 countsByYear W861690782015 @default.
• W86169078 countsByYear W861690782016 @default.
• W86169078 countsByYear W861690782017 @default.
• W86169078 countsByYear W861690782018 @default.
• W86169078 countsByYear W861690782019 @default.
• W86169078 countsByYear W861690782020 @default.
• W86169078 countsByYear W861690782021 @default.
• W86169078 countsByYear W861690782022 @default.
• W86169078 countsByYear W861690782023 @default.
• W86169078 crossrefType "journal-article" @default.
• W86169078 hasAuthorship W86169078A5030615975 @default.
• W86169078 hasAuthorship W86169078A5034746599 @default.
• W86169078 hasAuthorship W86169078A5044277046 @default.
• W86169078 hasAuthorship W86169078A5056482307 @default.
• W86169078 hasBestOaLocation W861690781 @default.
• W86169078 hasConcept C104317684 @default.
• W86169078 hasConcept C105580179 @default.
• W86169078 hasConcept C109159458 @default.
• W86169078 hasConcept C142669718 @default.
• W86169078 hasConcept C1491633281 @default.
• W86169078 hasConcept C189040839 @default.
• W86169078 hasConcept C20418707 @default.
• W86169078 hasConcept C2776636253 @default.
• W86169078 hasConcept C2778403015 @default.
• W86169078 hasConcept C2779012151 @default.
• W86169078 hasConcept C28328180 @default.
• W86169078 hasConcept C2909030593 @default.
• W86169078 hasConcept C54355233 @default.
• W86169078 hasConcept C55493867 @default.
• W86169078 hasConcept C58207958 @default.
• W86169078 hasConcept C86803240 @default.
• W86169078 hasConcept C95444343 @default.
• W86169078 hasConceptScore W86169078C104317684 @default.
• W86169078 hasConceptScore W86169078C105580179 @default.
• W86169078 hasConceptScore W86169078C109159458 @default.
• W86169078 hasConceptScore W86169078C142669718 @default.
• W86169078 hasConceptScore W86169078C1491633281 @default.
• W86169078 hasConceptScore W86169078C189040839 @default.
• W86169078 hasConceptScore W86169078C20418707 @default.
• W86169078 hasConceptScore W86169078C2776636253 @default.

• next