Matches in SemOpenAlex for { <https://semopenalex.org/work/W8620008> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W8620008 endingPage "70" @default.
- W8620008 startingPage "1667" @default.
- W8620008 abstract "ACTION OF CALCIUM ANTAGONISTS: In patients with chronic renal failure, controlling hypertension is an integral part of the therapeutic scheme aimed at preventing further degradation of renal function. Hypertension accelerates such degradation and inversely the renal disease aggravates hypertension. Normal blood pressure is thus crucial. Several studies have elucidated the action of calcium antagonists in these patients. KIDNEY TRANSPLANT RECIPIENTS: Calcium antagonists have several highly favorable effects on the transplanted kidney. These effects are explained by the attenuation of the ischemic effects of cyclosporin on the kidney. These patients should be given a calcium antagonist which does not raise the serum level of cyclosporin. DIABETIC NEPHROPATHY: In acute regimens, all calcium antagonists do not appear to have the same effect in patients with diabetic nephropathy. With the notable exception of nifedipine, calcium antagonists can lower acute proteinuria in these patients. Three controlled sudies conducted for more than 6 months have shown that the proteinuria lowering effect of calcium antagonists is equivalent to that of CEIs. Combined CEI and a calcium antagonist is probably the prescription of choice for these patients. Besides the antihypertensive synergism, this combination reduces the side effects of each class prescribed alone. In addition, there is experimental evidence supported by several clinical trials showing an improved nephroprotector effect compared with single prescription of each drug class alone. MECHANISMS OF NEPHROPROTECTION: Chronic renal failure results form intricated hemodynamic and cellular mechanisms. A lower intraglomerular hydrostatic pressure is a crucial element in nephroprotection. All the intrarenal effects of calcium antagonists have not been identified. Certain effects concern preglomerular vasodilatation alone while others have pre- and post-glomerular effects and thus have a potentially greater nephroprotector effect." @default.
- W8620008 created "2016-06-24" @default.
- W8620008 creator A5040938888 @default.
- W8620008 date "1999-10-09" @default.
- W8620008 modified "2023-09-26" @default.
- W8620008 title "[Nephro-protective effect of calcium antagonists]." @default.
- W8620008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10544702" @default.
- W8620008 hasPublicationYear "1999" @default.
- W8620008 type Work @default.
- W8620008 sameAs 8620008 @default.
- W8620008 citedByCount "4" @default.
- W8620008 crossrefType "journal-article" @default.
- W8620008 hasAuthorship W8620008A5040938888 @default.
- W8620008 hasConcept C126322002 @default.
- W8620008 hasConcept C170493617 @default.
- W8620008 hasConcept C2776741139 @default.
- W8620008 hasConcept C2776885963 @default.
- W8620008 hasConcept C2778653478 @default.
- W8620008 hasConcept C2779066535 @default.
- W8620008 hasConcept C2779561371 @default.
- W8620008 hasConcept C2779922275 @default.
- W8620008 hasConcept C2780091579 @default.
- W8620008 hasConcept C519063684 @default.
- W8620008 hasConcept C71924100 @default.
- W8620008 hasConcept C84393581 @default.
- W8620008 hasConcept C98274493 @default.
- W8620008 hasConceptScore W8620008C126322002 @default.
- W8620008 hasConceptScore W8620008C170493617 @default.
- W8620008 hasConceptScore W8620008C2776741139 @default.
- W8620008 hasConceptScore W8620008C2776885963 @default.
- W8620008 hasConceptScore W8620008C2778653478 @default.
- W8620008 hasConceptScore W8620008C2779066535 @default.
- W8620008 hasConceptScore W8620008C2779561371 @default.
- W8620008 hasConceptScore W8620008C2779922275 @default.
- W8620008 hasConceptScore W8620008C2780091579 @default.
- W8620008 hasConceptScore W8620008C519063684 @default.
- W8620008 hasConceptScore W8620008C71924100 @default.
- W8620008 hasConceptScore W8620008C84393581 @default.
- W8620008 hasConceptScore W8620008C98274493 @default.
- W8620008 hasIssue "30" @default.
- W8620008 hasLocation W86200081 @default.
- W8620008 hasOpenAccess W8620008 @default.
- W8620008 hasPrimaryLocation W86200081 @default.
- W8620008 hasRelatedWork W1964803013 @default.
- W8620008 hasRelatedWork W1990428506 @default.
- W8620008 hasRelatedWork W2046265272 @default.
- W8620008 hasRelatedWork W2054911035 @default.
- W8620008 hasRelatedWork W2056999032 @default.
- W8620008 hasRelatedWork W2074858950 @default.
- W8620008 hasRelatedWork W224749547 @default.
- W8620008 hasRelatedWork W2425873984 @default.
- W8620008 hasRelatedWork W2597345335 @default.
- W8620008 hasRelatedWork W75057367 @default.
- W8620008 hasVolume "28" @default.
- W8620008 isParatext "false" @default.
- W8620008 isRetracted "false" @default.
- W8620008 magId "8620008" @default.
- W8620008 workType "article" @default.