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- W86232451 abstract "Gene alterations play an important role in the origin and pathogenesis of human breast cancer. Three broad categories of gene changes that appear to contribute to tumor progression include tumor suppressor genes, repair-mutator genes, and oncogenes (1). Inherited defects in some somatic genes appear to be responsible for development of hereditary and familial breast cancer, estimated at 1% and 5%, respectively, of all breast cancer cases. Identified alterations include mutations in tumor suppressor genes such as p53 in Li-Fraumeni syndrome (2, 3). Mutations in the BRCA1 gene at chromosome 17q21 have been documented in familial breast cancer (4). A separate locus on chromosome 13q13, the BRCA2 gene, was also associated with familial breast cancer (5,6). Recent studies suggest that BRCA1 may represent a repair-mutator gene, a gene responsible for maintaining the fidelity of DNA duplication (7). The failure of gene surveillance can result in further alterations in gene function and thereby increase the mutation rate of other genes. Presumably, tumor suppressor genes and oncogenes would be prominent targets of faulty repair-mutator genes (1, 7)." @default.
- W86232451 created "2016-06-24" @default.
- W86232451 creator A5030502460 @default.
- W86232451 creator A5034694412 @default.
- W86232451 date "1999-01-01" @default.
- W86232451 modified "2023-09-27" @default.
- W86232451 title "Oncogene Activation and Breast Cancer Progression" @default.
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- W86232451 doi "https://doi.org/10.1007/978-1-59259-699-7_10" @default.
- W86232451 hasPublicationYear "1999" @default.