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• W862488326 abstract "Clinically, Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the development of tremors and rigidity that is found primarily in patients over the age of 50. At the cellular level, it is clear that the pathology of PD results from the progressive loss of dopaminergic neurons in the substantia nigra. Several lines of evidence have implicated oxidative stress as a contributing factor to the depletion of dopaminergic neurons in PD. Under conditions of oxidative stress, the neurotransmitter dopamine can be oxidized to form neurotoxic quinone and semiquinone products. While dopaquinones are known to be extremely reactive towards sulfhydryl groups of many cellular substrates, mounting evidence suggests that their toxic effects can be quenched by intrinsic antioxidant mechanisms (e.g., glutathione). However, to respond appropriately to differing levels of oxidative stress, cells require a mechanism to regulate an appropriate response. This manuscript proposes metallothionein as a major cellular sensor of oxidized dopamine stress and metallothionein-mediated Zn 2+ mobilization as an effecter signal that is used by the cell to manage oxidized dopamine as an intrinsic neurotoxin." @default.
• W862488326 created "2016-06-24" @default.
• W862488326 creator A5003253550 @default.
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• W862488326 date "2010-03-01" @default.
• W862488326 modified "2023-10-13" @default.
• W862488326 title "Zinc–metallothionein: a potential mediator of antioxidant defence mechanisms in response to dopamine-induced stressThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease." @default.
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• W862488326 doi "https://doi.org/10.1139/y10-022" @default.
• W862488326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20393595" @default.
• W862488326 hasPublicationYear "2010" @default.
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