Matches in SemOpenAlex for { <https://semopenalex.org/work/W86278982> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W86278982 endingPage "30" @default.
- W86278982 startingPage "523" @default.
- W86278982 abstract "1-(2-Methoxy-2-phenyl)-ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)-propyl-iperazine-dihydrochloride (zipeprol, Respilene) is a substance of non-phenanthrenic chemical structure. In the cat, it antagonised cough induced by stimulation of the superior laryngeal nerve or by direct mechanical excitation of the sensitive tracheo-bronchial receptors. The efficacy of zipeprol after enteral administration made it possible both to establish good intestinal absorption and to rank it favourably in relation to several major antitussive reference products; codeine, codethyline, dextromethorphan, diphenhydramine and pentoxyverine. The activity of zipeprol was superior or equal to that of all these substances, excdept codeine. The antitussive properties appeared to be due to a central action. Other properties have been demonstrated which suggest at least a supplementary mechanism in the inhibition of cough, in addition to the central action. These consisted of slight antihistamine and anticholinergic properties, marked local-anesthetic potency and bronchospasmolytic activity. This latter property was demonstrated by the inhibition of histamine and serotonin induced bronchospasm in the guinea-pig. In vitro, using human sputum, zipeprol had a mucolytic action, shown by a decrease in sputum vis viscosity and lysis of DNA and AMPS fibrils. In the dog, at high doses, zipeprol unlike codeine, did not inhibit central stimulation of respiration by hypercapnia, in addition no modification of ventilatory dynamics or blood gases was seen. On the basis of these results, zipeprol can be considered as possessing no respiratory depressant effect even in the upper ranges of its antitussive doses." @default.
- W86278982 created "2016-06-24" @default.
- W86278982 creator A5022250788 @default.
- W86278982 creator A5029695540 @default.
- W86278982 creator A5035478448 @default.
- W86278982 creator A5039220650 @default.
- W86278982 creator A5044394768 @default.
- W86278982 date "1976-04-01" @default.
- W86278982 modified "2023-10-18" @default.
- W86278982 title "General pharmacological properties of a new non-opiate antitussive: zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity." @default.
- W86278982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8057" @default.
- W86278982 hasPublicationYear "1976" @default.
- W86278982 type Work @default.
- W86278982 sameAs 86278982 @default.
- W86278982 citedByCount "4" @default.
- W86278982 crossrefType "journal-article" @default.
- W86278982 hasAuthorship W86278982A5022250788 @default.
- W86278982 hasAuthorship W86278982A5029695540 @default.
- W86278982 hasAuthorship W86278982A5035478448 @default.
- W86278982 hasAuthorship W86278982A5039220650 @default.
- W86278982 hasAuthorship W86278982A5044394768 @default.
- W86278982 hasConcept C1122143 @default.
- W86278982 hasConcept C126322002 @default.
- W86278982 hasConcept C185592680 @default.
- W86278982 hasConcept C24998067 @default.
- W86278982 hasConcept C2777389121 @default.
- W86278982 hasConcept C2777866328 @default.
- W86278982 hasConcept C2781245242 @default.
- W86278982 hasConcept C2781292560 @default.
- W86278982 hasConcept C42219234 @default.
- W86278982 hasConcept C71924100 @default.
- W86278982 hasConcept C98274493 @default.
- W86278982 hasConceptScore W86278982C1122143 @default.
- W86278982 hasConceptScore W86278982C126322002 @default.
- W86278982 hasConceptScore W86278982C185592680 @default.
- W86278982 hasConceptScore W86278982C24998067 @default.
- W86278982 hasConceptScore W86278982C2777389121 @default.
- W86278982 hasConceptScore W86278982C2777866328 @default.
- W86278982 hasConceptScore W86278982C2781245242 @default.
- W86278982 hasConceptScore W86278982C2781292560 @default.
- W86278982 hasConceptScore W86278982C42219234 @default.
- W86278982 hasConceptScore W86278982C71924100 @default.
- W86278982 hasConceptScore W86278982C98274493 @default.
- W86278982 hasIssue "4" @default.
- W86278982 hasLocation W862789821 @default.
- W86278982 hasOpenAccess W86278982 @default.
- W86278982 hasPrimaryLocation W862789821 @default.
- W86278982 hasRelatedWork W1976601877 @default.
- W86278982 hasRelatedWork W1991894924 @default.
- W86278982 hasRelatedWork W2013286654 @default.
- W86278982 hasRelatedWork W2054325883 @default.
- W86278982 hasRelatedWork W2055345153 @default.
- W86278982 hasRelatedWork W2083782900 @default.
- W86278982 hasRelatedWork W2419648229 @default.
- W86278982 hasRelatedWork W2439806250 @default.
- W86278982 hasRelatedWork W7485506 @default.
- W86278982 hasRelatedWork W86278982 @default.
- W86278982 hasVolume "26" @default.
- W86278982 isParatext "false" @default.
- W86278982 isRetracted "false" @default.
- W86278982 magId "86278982" @default.
- W86278982 workType "article" @default.