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• W86281337 abstract "Hyaluronan (HA) can be fabricated into a number of different physical formats including liquids of various viscosities, strands, weaves, sponges and fleeces. All of these formats have uses as delivery vehicles for cells or bioactive molecules for implantation into in vivo sites. Moreover, the physical, chemical, and biological properties of these HA scaffolds can be altered to provide different breakdown kinetics, different cell and molecular attachment domains, and different porosities and hydrophobicities. Importantly, HA in high and low molecular weight configurations have been shown to have different inductive, inhibitory or stimulatory effects on certain cell types. Thus, HA delivery vehicles could be used in a variety of Tissue Engineering constructs. We have used HA sponges to investigate their intrinsic and extrinsic repair/ regeneration potential in a full-thickness osteochondral defect in rabbit knees. The results provide the basis for defining the optimal characteristics of this class of delivery vehicles for skeletal tissue regeneration. Specifically, multifunctional delivery vehicles are required and they must exhibit different signaling capabilities at different stages of the repair process. By controlling the intrinsic breakdown characteristics of these HA delivery vehicles, the kinetics and sequence of the repair process can be precisely controlled. In other words, the change in phase of the delivery vehicle from high to low molecular weight polymer can be the trigger for several biological events. Indeed, the release of HA oligomers has profound biological ramifications in in vivo sites. Both theoretical and practical information forms the basis for considering HA scaffolds for use in Tissue Engineering strategies especially for the regeneration of skeletal tissues." @default.
• W86281337 created "2016-06-24" @default.
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• W86281337 date "2002-01-01" @default.
• W86281337 modified "2023-09-23" @default.
• W86281337 title "HYALURONAN AND TISSUE ENGINEERING" @default.
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• W86281337 doi "https://doi.org/10.1533/9781845693121.45" @default.
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