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- W862828802 abstract "The development of a universal influenza vaccine that provides broad cross protection against existing and unforeseen influenza viruses is a critical challenge. In this study, we constructed and expressed conserved sM2 and HA2 influenza antigens with cholera toxin subunit A1 (CTA1) on the surface of Lactobacillus casei (pgsA-CTA1sM2HA2/L. casei). Oral and nasal administrations of recombinant L. casei into mice resulted in high levels of serum immunoglobulin G (IgG) and their isotypes (IgG1 & IgG2a) as well as mucosal IgA. The mucosal administration of pgsA-CTA1sM2HA2/L. casei may also significantly increase the levels of sM2- or HA2-specific cell-mediated immunity because increased release of both IFN-γ and IL-4 was observed. The recombinant pgsA-CTA1sM2HA2/L. casei provided better protection of BALB/c mice against 10 times the 50% mouse lethal doses (MLD50) of homologous A/EM/Korea/W149/06(H5N1) or A/Aquatic bird/Korea/W81/2005 (H5N2) and heterologous A/Puerto Rico/8/34(H1N1), or A/Chicken/Korea/116/2004(H9N2) or A/Philippines/2/08(H3N2) viruses, compared with L. casei harboring sM2HA2 and also the protection was maintained up to seven months after administration. These results indicate that recombinant L. casei expressing the highly conserved sM2, HA2 of influenza and CTA1 as a mucosal adjuvant could be a potential mucosal vaccine candidate or tool to protect against divergent influenza viruses for human and animal." @default.
- W862828802 created "2016-06-24" @default.
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- W862828802 date "2015-09-01" @default.
- W862828802 modified "2023-10-18" @default.
- W862828802 title "Mucosally administered Lactobacillus surface-displayed influenza antigens (sM2 and HA2) with cholera toxin subunit A1 (CTA1) Induce broadly protective immune responses against divergent influenza subtypes" @default.
- W862828802 cites W1482903412 @default.
- W862828802 cites W1592362980 @default.
- W862828802 cites W1605296331 @default.
- W862828802 cites W1655706054 @default.
- W862828802 cites W1904826643 @default.
- W862828802 cites W1911055492 @default.
- W862828802 cites W1963594199 @default.
- W862828802 cites W1966823964 @default.
- W862828802 cites W1968114019 @default.
- W862828802 cites W1976609017 @default.
- W862828802 cites W1979364782 @default.
- W862828802 cites W1984412128 @default.
- W862828802 cites W1984811926 @default.
- W862828802 cites W1986242981 @default.
- W862828802 cites W1989357171 @default.
- W862828802 cites W1995488823 @default.
- W862828802 cites W1996776152 @default.
- W862828802 cites W2000761349 @default.
- W862828802 cites W2001953488 @default.
- W862828802 cites W2002392006 @default.
- W862828802 cites W2007047843 @default.
- W862828802 cites W2012072069 @default.
- W862828802 cites W2013573733 @default.
- W862828802 cites W2013574284 @default.
- W862828802 cites W2020398539 @default.
- W862828802 cites W2023631869 @default.
- W862828802 cites W2024238985 @default.
- W862828802 cites W2025673256 @default.
- W862828802 cites W2028372889 @default.
- W862828802 cites W2029884055 @default.
- W862828802 cites W2032512723 @default.
- W862828802 cites W2035068182 @default.
- W862828802 cites W2038508954 @default.
- W862828802 cites W2040388426 @default.
- W862828802 cites W2042580604 @default.
- W862828802 cites W2045446870 @default.
- W862828802 cites W2054370814 @default.
- W862828802 cites W2055920579 @default.
- W862828802 cites W2067684202 @default.
- W862828802 cites W2068957604 @default.
- W862828802 cites W2069672057 @default.
- W862828802 cites W2070736580 @default.
- W862828802 cites W2071657440 @default.
- W862828802 cites W2077308524 @default.
- W862828802 cites W2087550518 @default.
- W862828802 cites W2097383406 @default.
- W862828802 cites W2098658882 @default.
- W862828802 cites W2101943349 @default.
- W862828802 cites W2102335249 @default.
- W862828802 cites W2103366618 @default.
- W862828802 cites W2108365406 @default.
- W862828802 cites W2108838669 @default.
- W862828802 cites W2110062172 @default.
- W862828802 cites W2111970140 @default.
- W862828802 cites W2127920839 @default.
- W862828802 cites W2140534523 @default.
- W862828802 cites W2149719404 @default.
- W862828802 cites W2152398830 @default.
- W862828802 cites W2154116964 @default.
- W862828802 cites W2154410678 @default.
- W862828802 cites W2155069724 @default.
- W862828802 cites W2155149543 @default.
- W862828802 cites W2155851157 @default.
- W862828802 cites W2161870183 @default.
- W862828802 cites W2165532966 @default.
- W862828802 cites W2168513578 @default.
- W862828802 cites W2170319845 @default.
- W862828802 cites W2173375845 @default.
- W862828802 doi "https://doi.org/10.1016/j.vetmic.2015.07.020" @default.
- W862828802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26210951" @default.
- W862828802 hasPublicationYear "2015" @default.
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