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• W86284402 abstract "Back to table of contents Previous article Next article No AccessMelancholic/endogenous depression and response to somatic treatment and placeboPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.149.10.1324AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The authors' goals were to examine the effects of somatic treatment and placebo in patients with and without endogenous/melancholic depression. METHOD: Before entry into one of four trials of antidepressant drugs versus placebo, 231 patients were assessed as to whether they met Research Diagnostic Criteria for definite endogenous depression and/or DSM-III criteria for major depressive episode with melancholia. These patients were prospectively assessed for subsequent response to antidepressant treatment or placebo. Previous studies of the effect of endogenous/melancholic depression on treatment response were also reviewed. RESULTS: Of the 76 patients with DSM-III melancholia given active medication, 41 (54%) had a complete or partial response, but only 10 (23%) of the 44 patients with melancholia given placebo had a complete or partial response. Of the 76 depressed patients without melancholia given active medication, 46 (61%) had a complete or partial response, and 15 (43%) of the 35 depressed patients without melancholia given placebo had a complete or partial response. Moderately depressed patients with DSM-III melancholia had a significantly better response to active medication than did severely depressed patients with melancholia and showed the greatest difference between response to active medication and response to placebo. The results of the review of previous studies of the effect of endogenous/melancholic depression on treatment response were mixed. CONCLUSIONS: Depressed patients with melancholia were not particularly different from depressed patients without melancholia in their responses to antidepressant medication but did differ from patients without melancholia in their responses to active medication versus placebo, particularly if their depression was moderate and not severe. This suggests that patients with DSM-III melancholia may be unresponsive to nonsomatic treatments. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byDiagnosing Depression18 August 2022Preliminary Evidence for Sociotropy and Autonomy in Relation to Antidepressant Treatment Outcome10 February 2021 | Psychiatric Quarterly, Vol. 92, No. 3Melancholic features (DSM-IV) predict but do not moderate response to antidepressants in major depression: an individual participant data meta-analysis of 1219 patients26 July 2020 | European Archives of Psychiatry and Clinical Neuroscience, Vol. 271, No. 3Antidepressant responses in direct comparisons of melancholic and non-melancholic depression9 September 2020 | Journal of Psychopharmacology, Vol. 34, No. 12Melancholia: does this ancient concept have contemporary utility?16 March 2020 | International Review of Psychiatry, Vol. 32, No. 5-6Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disordersJournal of Affective Disorders, Vol. 238A quantitative review on outcome-to-antidepressants in melancholic unipolar depressionPsychiatry Research, Vol. 265A randomized clinical trial comparing two two‐phase treatment strategies for in‐patients with severe depression6 May 2017 | Acta Psychiatrica Scandinavica, Vol. 136, No. 1Asian Journal of Psychiatry, Vol. 26Journal of Affective Disorders, Vol. 191Psychiatry Research, Vol. 238Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders7 December 2015 | Australian & New Zealand Journal of Psychiatry, Vol. 49, No. 12Psychopharmacology, Vol. 232, No. 20International Journal of Neuropsychopharmacology, Vol. 18, No. 10Journal of Affective Disorders, Vol. 144, No. 1-2Acta Psychiatrica ScandinavicaNeuropsychobiology, Vol. 67, No. 1Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features9 February 2012 | Therapeutic Advances in Psychopharmacology, Vol. 2, No. 2Baseline mood-state measures as predictors of antidepressant response to scopolaminePsychiatry Research, Vol. 196, No. 1PLoS ONE, Vol. 7, No. 10Pain Has a Strong Negative Impact on the Fluoxetine Response in Hospitalized Patients With Major Depressive DisorderThe Clinical Journal of Pain, Vol. 27, No. 9Randomized comparison of selective serotonin reuptake inhibitor (escitalopram) monotherapy and antidepressant combination pharmacotherapy for major depressive disorder with melancholic features: A CO-MED reportJournal of Affective Disorders, Vol. 133, No. 3Journal of Affective Disorders, Vol. 132, No. 1-2Acta Psychiatrica Scandinavica, Vol. 123, No. 1Disease versus Dimension in Diagnosis1 October 2010 | The Canadian Journal of Psychiatry, Vol. 55, No. 10Depression and Anxiety, Vol. 26, No. 9Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant DepressionBiological Psychiatry, Vol. 64, No. 6Acta Psychiatrica Scandinavica, Vol. 115, No. s433Behavioural Pharmacology, Vol. 16, No. 5-6BMC Psychiatry, Vol. 5, No. 1Neuropsychopharmacology, Vol. 29, No. 2Australian & New Zealand Journal of Psychiatry, Vol. 38, No. 6Cognitive Behavior Therapy for Depression? Choose Horses for CoursesGordon Parker, D.Sc., M.D., Ph.D., F.R.A.N.Z.C.P., Kay Roy, B.A., and Kerrie Eyers, M.A., M.P.H., M.A.P.S.1 May 2003 | American Journal of Psychiatry, Vol. 160, No. 5A Reevaluation of the Exclusion Criteria Used in Antidepressant Efficacy TrialsMichael A. Posternak, M.D., Mark Zimmerman, M.D., Gabor I. Keitner, M.D., and Ivan W. Miller, Ph.D.1 February 2002 | American Journal of Psychiatry, Vol. 159, No. 2CNS Drugs, Vol. 15, No. 10Are the Newer Antidepressant Drugs as Effective as Established Physical Treatments? Results from an Australasian Clinical Panel Review17 November 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 33, No. 6The Place for the Tricyclic Antidepressants in the Treatment of Depression17 November 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 33, No. 3Journal of Affective Disorders, Vol. 52, No. 1-3Psychiatry Research, Vol. 86, No. 3Human Psychopharmacology: Clinical and Experimental, Vol. 13, No. 1Acta Psychiatrica Scandinavica, Vol. 98, No. 4Australasian Journal on Ageing, Vol. 17, No. 2Biological Psychiatry, Vol. 42, No. 7Journal of Affective Disorders, Vol. 41, No. 3Acta Psychiatrica Scandinavica, Vol. 94, No. 5Journal of Clinical Psychopharmacology, Vol. 15, No. 6Treatment Resistant Depression in an Australian Context I: The Utility of the Term and Approaches to Management26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 28, No. 1Journal of Affective Disorders, Vol. 30, No. 3Journal of Affective Disorders, Vol. 31, No. 4Dr. Peselow RepliesERIC D. PESELOW1 April 2006 | American Journal of Psychiatry, Vol. 150, No. 11Visual hallucinations in macular degeneration1 April 2006 | American Journal of Psychiatry, Vol. 150, No. 11Response to somatic treatment and placebo in patients with melancholia/endogenous depression1 April 2006 | American Journal of Psychiatry, Vol. 150, No. 11Journal of Psychiatric Research, Vol. 27, No. 3 Volume 149Issue 10 October 1992Pages 1324-1334 Metrics PDF download History Published online 1 April 2006 Published in print 1 October 1992" @default.
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