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- W86325814 abstract "A unique feature of N-methyl-D-aspartate receptors (NMDARs) that distinguishes them from other ionic receptors is that their activation requires more than one agonist to bind simultaneously to distinct binding sites on the receptor. D-serine, a co-agonist binding to the glycine site of NMDARs, has been implicated in several NMDAR-dependent physiological processes, and altered D-serine levels under certain pathophysiological conditions contribute to neural dysfunction via NMDARs in the central nervous system. Entry of HIV-1 in the brain causes neuronal injury leading to cognitive, behavioral and motor impairments known as HIV-associated neurocognitive disorders (HAND). As HIV-1 does not infect neurons, neuronal injury is believed to be primarily mediated by an indirect mechanism,that is, HIV-1-infected and/or immune-activated macrophages and microglial cells release soluble molecules leading to neuronal injury or death. Among the soluble factors is D-serine. In this article we try to address recent progresses on the role D-serine might play in the pathogenesis of neurodegenerative disorders with a particular emphasis of the involvement of D-serine in HIV-1-associated neurotoxicity." @default.
- W86325814 created "2016-06-24" @default.
- W86325814 creator A5035117703 @default.
- W86325814 creator A5059449237 @default.
- W86325814 date "2013-09-10" @default.
- W86325814 modified "2023-09-23" @default.
- W86325814 title "Neuropathogenesis of HIV-1-associated neurocognitive disorders: a possible involvement of D-serine." @default.
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- W86325814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3773073" @default.
- W86325814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24044033" @default.
- W86325814 hasPublicationYear "2013" @default.
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