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- W86451888 abstract "Breast cancer is the most common malignancy among women worldwide and is a leading cause of death; it metastasizes frequently to bone. Anti-resorptive drugs such as bisphosphonates (of which the aminobisphosphonate zoledronic acid is the most potent one) or the anti-Rank-ligand antibody denosumab, are used both for the treatment of bone metastases and for treating and or preventing osteoporosis. Recently, these drugs have also been investigated in large clinical trials as to whether their adjuvant use can improve outcomes of early breast cancer patients, based on the prevention of metastases. Trials results of large adjuvant zoledronic acid trials have been presented but are, however, conflicting. Whereas ABCSG-12 and ZO-FAST demonstrate clear-cut outcome benefits based on the prevention of metastases in bone and outside bone, AZURE overall did not show a significant difference. In the post-menopausal subgroup, however, AZURE also demonstrated significant disease-free and overall survival benefits for patients treated with zoledronic acid. Similar observations in other bisphosphonate trials have led to the hypothesis that the endocrine environment may play an important role in determining the anti-cancer effects of anti-resorptive drugs. A recent EBCTCG individual patient-level meta-analysis has confirmed a significant benefit of adjuvant bisphosphonates in a low-estrogen environment, either in post-menopausal patients or pre-menopausal patients treated with ovarian function suppression. Ongoing large trials will show whether any of this is also true for the adjuvant use of denosumab." @default.
- W86451888 created "2016-06-24" @default.
- W86451888 creator A5001256203 @default.
- W86451888 date "2015-01-01" @default.
- W86451888 modified "2023-09-24" @default.
- W86451888 title "Bone metastases, clinical trials II: zoledronic acid and denosumab in the prevention of bone metastases" @default.
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- W86451888 doi "https://doi.org/10.1016/b978-0-12-416721-6.00058-3" @default.
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